TNF-alpha but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis.

  • Authors:
    • E Mariani
    • A Tarozzi
    • A Meneghetti
    • L Cattini
    • A Facchini
  • View Affiliations

  • Published online on: August 1, 1998     https://doi.org/10.3892/ijo.13.2.349
  • Pages: 349-402
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Abstract

TNF-alpha-treated osteosarcoma cells have an enhanced susceptibility to NK lysis which mostly depends on the increased expression of CD54 molecules. Since IL-1 and IL-6 share overlapping biological properties with TNF-alpha, we investigated whether the treatment of osteosarcoma cells with these cytokines could modify their susceptibility to NK lysis and whether these modifications were related to a different distribution of CD54, CD56 and CD58 molecules. We demonstrated that the expression of CD54 and CD58 on osteosarcomas correlated positively with the susceptibility to NK lysis and that this susceptibility was enhanced by TNF-alpha treatment but not by IL-1 and IL-6 stimulation.

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Aug 1998
Volume 13 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Mariani E, Tarozzi A, Meneghetti A, Cattini L and Facchini A: TNF-alpha but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis.. Int J Oncol 13: 349-402, 1998
APA
Mariani, E., Tarozzi, A., Meneghetti, A., Cattini, L., & Facchini, A. (1998). TNF-alpha but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis.. International Journal of Oncology, 13, 349-402. https://doi.org/10.3892/ijo.13.2.349
MLA
Mariani, E., Tarozzi, A., Meneghetti, A., Cattini, L., Facchini, A."TNF-alpha but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis.". International Journal of Oncology 13.2 (1998): 349-402.
Chicago
Mariani, E., Tarozzi, A., Meneghetti, A., Cattini, L., Facchini, A."TNF-alpha but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis.". International Journal of Oncology 13, no. 2 (1998): 349-402. https://doi.org/10.3892/ijo.13.2.349