Microtubule-damaging drugs triggered bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl2 protein.

  • Authors:
    • A Basu
    • S Haldar
  • View Affiliations

  • Published online on: October 1, 1998     https://doi.org/10.3892/ijo.13.4.659
  • Pages: 659-723
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Abstract

Specifically anti-microtubule agents such as taxol, vincristine, vinblastine and dolastatin can trigger Bcl2 phosphorylation at G2-M phase of the cell cycle in malignant cells derived from a variety of human cancers. In this study, the status of Bcl2 phosphorylation was investigated in response to more antimicrotubule agents such as colchicine, colcemid or podophyllotoxin. Although these agents are not currently used for cancer therapy, they were able to trigger Bcl2 phosphorylation with simultaneous apoptosis in cancer cells. Previously, by using extensive site-directed mutagenesis studies we determined that mutation of serine-70 to alanine could not completely abrogate taxol induced Bcl2 phosphorylation. Studies reported here clearly indicate that serine-87 residue along with serine-70 of Bcl2 protein are necessary for microtubule damaging drug induced phosphorylation.

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Oct 1998
Volume 13 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Basu A and Basu A: Microtubule-damaging drugs triggered bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl2 protein.. Int J Oncol 13: 659-723, 1998
APA
Basu, A., & Basu, A. (1998). Microtubule-damaging drugs triggered bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl2 protein.. International Journal of Oncology, 13, 659-723. https://doi.org/10.3892/ijo.13.4.659
MLA
Basu, A., Haldar, S."Microtubule-damaging drugs triggered bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl2 protein.". International Journal of Oncology 13.4 (1998): 659-723.
Chicago
Basu, A., Haldar, S."Microtubule-damaging drugs triggered bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl2 protein.". International Journal of Oncology 13, no. 4 (1998): 659-723. https://doi.org/10.3892/ijo.13.4.659