Expression of platelet-derived endothelial cell growth factor in non-small cell lung carcinomas: relationship to various biological factors.

  • Authors:
    • M Volm
    • J Mattern
    • R Koomagi
  • View Affiliations

  • Published online on: November 1, 1998     https://doi.org/10.3892/ijo.13.5.975
  • Pages: 975-984
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Abstract

The expression of platelet-derived endothelial cell growth factor (PD-ECGF) was determined immunohistochemically in 143 non-small cell lung carcinomas. Staining was observed in 48% of the cases. A relationship between histology, stage, erbB-1, erbB-2, ras and PD-ECGF expression was not found. A relationship of borderline significance was observed between PD-ECGF and p53 expression. There was also no relationship between PD-ECGF expression and proliferative activity (G1 phases, S phases, cyclin A). In contrast, a correlation between PD-ECGF- and VEGF-expression was detectable (p=0.009). Furthermore, PD-ECGF expression was related to the response of lung carcinomas to doxorubicin (p=0.0004). Of 35 sensitive tumors, 26 carcinomas were PD-ECGF-positive (74%) while of 108 resistant carcinomas only 43 tumors (40%) exhibited PD-ECGF expression.

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Nov 1998
Volume 13 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Volm M, Mattern J and Koomagi R: Expression of platelet-derived endothelial cell growth factor in non-small cell lung carcinomas: relationship to various biological factors.. Int J Oncol 13: 975-984, 1998
APA
Volm, M., Mattern, J., & Koomagi, R. (1998). Expression of platelet-derived endothelial cell growth factor in non-small cell lung carcinomas: relationship to various biological factors.. International Journal of Oncology, 13, 975-984. https://doi.org/10.3892/ijo.13.5.975
MLA
Volm, M., Mattern, J., Koomagi, R."Expression of platelet-derived endothelial cell growth factor in non-small cell lung carcinomas: relationship to various biological factors.". International Journal of Oncology 13.5 (1998): 975-984.
Chicago
Volm, M., Mattern, J., Koomagi, R."Expression of platelet-derived endothelial cell growth factor in non-small cell lung carcinomas: relationship to various biological factors.". International Journal of Oncology 13, no. 5 (1998): 975-984. https://doi.org/10.3892/ijo.13.5.975