A third human CBL gene is on chromosome 19.

  • Authors:
    • V Ollendorff
    • M Mattei
    • E Fournier
    • J Adelaide
    • M Lopez
    • O Rosnet
    • D Birnbaum
  • View Affiliations

  • Published online on: December 1, 1998     https://doi.org/10.3892/ijo.13.6.1159
  • Pages: 1159-1220
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Abstract

CBL genes encode cytoplasmic proteins involved in signal transduction downstream of a number of receptors including tyrosine kinases, cytokine receptors, and T-cell or B-cell receptors. They seem to be transducers associated with negative regulation of signals, and, as such, may be potential tumor suppressors. Using a probe derived from an expressed sequence tag, we isolated a cosmid containing part of a new CBL gene, CBLc, related to the two characterized paralogous genes CBLa and CBLb. Using the cosmid in fluorescence in situ hybridization of human metaphase chromosomes, we localized the CBLc gene to band 13.2 of chromosome 19. We show that the 19q12.2-13.3 region where CBLc is located shows paralogy with two other regions of the human genome, 3q22-q27 and 11q22-q24 where CBLb and CBLa are located, respectively. Genes from several other families are located in these regions.

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Dec 1998
Volume 13 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Ollendorff V, Mattei M, Fournier E, Adelaide J, Lopez M, Rosnet O and Birnbaum D: A third human CBL gene is on chromosome 19.. Int J Oncol 13: 1159-1220, 1998
APA
Ollendorff, V., Mattei, M., Fournier, E., Adelaide, J., Lopez, M., Rosnet, O., & Birnbaum, D. (1998). A third human CBL gene is on chromosome 19.. International Journal of Oncology, 13, 1159-1220. https://doi.org/10.3892/ijo.13.6.1159
MLA
Ollendorff, V., Mattei, M., Fournier, E., Adelaide, J., Lopez, M., Rosnet, O., Birnbaum, D."A third human CBL gene is on chromosome 19.". International Journal of Oncology 13.6 (1998): 1159-1220.
Chicago
Ollendorff, V., Mattei, M., Fournier, E., Adelaide, J., Lopez, M., Rosnet, O., Birnbaum, D."A third human CBL gene is on chromosome 19.". International Journal of Oncology 13, no. 6 (1998): 1159-1220. https://doi.org/10.3892/ijo.13.6.1159