Menadione (vitamin K3) enhances the mitogenic signal of epidermal growth factor via extracellular signal-regulated kinases.

  • Authors:
    • J Markovits
    • T P Sun
    • C C Juan
    • G C Ju
    • F Y Wu
  • View Affiliations

  • Published online on: December 1, 1998     https://doi.org/10.3892/ijo.13.6.1163
  • Pages: 1163-1233
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Abstract

The effects of vitamin K3 (VK3) on DNA synthesis, cell proliferation and mitogen-activated protein kinase pathway were investigated in G0-arrested NIH 3T3 fibroblasts. VK3 (5 microM) alone stimulates DNA synthesis by 40% and moderately increases the mitogenic effects of EGF, which is preceded by a rapid phosphorylation of the extracellular signal-regulated kinases (ERKs). At 20 microM, VK3 had an antiproliferative effect. VK3 alone (5 and 50 microM) or in concert with EGF increases the activity of ERK2 (by 2.5 and 5 fold, respectively). Our studies demonstrate that the activation of ERKs by VK3 alone, or VK3 plus EGF can promote either stimulatory or inhibitory effects on the mitogenic signal.

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Dec 1998
Volume 13 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Markovits J, Sun T, Juan C, Ju G and Wu F: Menadione (vitamin K3) enhances the mitogenic signal of epidermal growth factor via extracellular signal-regulated kinases.. Int J Oncol 13: 1163-1233, 1998
APA
Markovits, J., Sun, T., Juan, C., Ju, G., & Wu, F. (1998). Menadione (vitamin K3) enhances the mitogenic signal of epidermal growth factor via extracellular signal-regulated kinases.. International Journal of Oncology, 13, 1163-1233. https://doi.org/10.3892/ijo.13.6.1163
MLA
Markovits, J., Sun, T., Juan, C., Ju, G., Wu, F."Menadione (vitamin K3) enhances the mitogenic signal of epidermal growth factor via extracellular signal-regulated kinases.". International Journal of Oncology 13.6 (1998): 1163-1233.
Chicago
Markovits, J., Sun, T., Juan, C., Ju, G., Wu, F."Menadione (vitamin K3) enhances the mitogenic signal of epidermal growth factor via extracellular signal-regulated kinases.". International Journal of Oncology 13, no. 6 (1998): 1163-1233. https://doi.org/10.3892/ijo.13.6.1163