Tranilast and cisplatin as an experimental combination therapy for scirrhous gastric cancer.

  • Authors:
    • K Murahashi
    • M Yashiro
    • T Inoue
    • S Nishimura
    • T Matsuoka
    • T Sawada
    • M Sowa
    • K Hirakawa-Ys Chung
  • View Affiliations

  • Published online on: December 1, 1998     https://doi.org/10.3892/ijo.13.6.1235
  • Pages: 1235-1275
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Abstract

We examined the effect of Tranilast on the reduction of the administered dose of cisplatin using a scirrhous gastric cancer model. Scirrhous gastric cancer cell line, OCUM-2M, and gastric fibroblasts, NF-10, were used. The IC50 values of CDDP to OCUM-2M cells were decreased by Tranilast in vitro. The combination treatment with Tranilast and CDDP decreased the xenografted tumor size. The combination therapy decreased fibrosis and mitosis, and increased apoptosis. These findings suggest that Tranilast increased the CDDP response on scirrhous gastric cancer. The combination treatment with Tranilast and CDDP may be useful as a new therapy for scirrhous gastric carcinoma.

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Dec 1998
Volume 13 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Murahashi K, Yashiro M, Inoue T, Nishimura S, Matsuoka T, Sawada T, Sowa M and Hirakawa-Ys Chung K: Tranilast and cisplatin as an experimental combination therapy for scirrhous gastric cancer.. Int J Oncol 13: 1235-1275, 1998
APA
Murahashi, K., Yashiro, M., Inoue, T., Nishimura, S., Matsuoka, T., Sawada, T. ... Hirakawa-Ys Chung, K. (1998). Tranilast and cisplatin as an experimental combination therapy for scirrhous gastric cancer.. International Journal of Oncology, 13, 1235-1275. https://doi.org/10.3892/ijo.13.6.1235
MLA
Murahashi, K., Yashiro, M., Inoue, T., Nishimura, S., Matsuoka, T., Sawada, T., Sowa, M., Hirakawa-Ys Chung, K."Tranilast and cisplatin as an experimental combination therapy for scirrhous gastric cancer.". International Journal of Oncology 13.6 (1998): 1235-1275.
Chicago
Murahashi, K., Yashiro, M., Inoue, T., Nishimura, S., Matsuoka, T., Sawada, T., Sowa, M., Hirakawa-Ys Chung, K."Tranilast and cisplatin as an experimental combination therapy for scirrhous gastric cancer.". International Journal of Oncology 13, no. 6 (1998): 1235-1275. https://doi.org/10.3892/ijo.13.6.1235