Antitumor effect of vesnarinone on human hepatocellular carcinoma cell lines.

  • Authors:
    • K Kubo
    • Y Matsuzaki
    • A Kato
    • S Terai
    • K Okita
  • View Affiliations

  • Published online on: January 1, 1999     https://doi.org/10.3892/ijo.14.1.41
  • Pages: 41-47
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Abstract

Vesnarinone, a quinolinone derivative, induces apoptosis and differentiation in some tumor cell lines. We examined the antitumor effect of vesnarinone on three human hepatocellular carcinoma (HCC) cell lines. Vesnarinone suppressed the proliferation of all three HCC cell lines, but did not induce apoptosis and differentiation. Vesnarinone has also been reported to inhibit both nucleoside and nucleobase transport. Concomitant administration of vesnarinone and a de novo nucleotide synthesis inhibitor potentiated the growth-inhibitory effect of vesnarinone on HCC cells. Vesnarinone may be useful as a new biochemical modulator of anticancer agents.

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Jan 1999
Volume 14 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kubo K, Matsuzaki Y, Kato A, Terai S and Okita K: Antitumor effect of vesnarinone on human hepatocellular carcinoma cell lines.. Int J Oncol 14: 41-47, 1999
APA
Kubo, K., Matsuzaki, Y., Kato, A., Terai, S., & Okita, K. (1999). Antitumor effect of vesnarinone on human hepatocellular carcinoma cell lines.. International Journal of Oncology, 14, 41-47. https://doi.org/10.3892/ijo.14.1.41
MLA
Kubo, K., Matsuzaki, Y., Kato, A., Terai, S., Okita, K."Antitumor effect of vesnarinone on human hepatocellular carcinoma cell lines.". International Journal of Oncology 14.1 (1999): 41-47.
Chicago
Kubo, K., Matsuzaki, Y., Kato, A., Terai, S., Okita, K."Antitumor effect of vesnarinone on human hepatocellular carcinoma cell lines.". International Journal of Oncology 14, no. 1 (1999): 41-47. https://doi.org/10.3892/ijo.14.1.41