TGFbeta-induced growth inhibition involves cell cycle inhibitor p21 and pRb independent from p15 expression.

  • Authors:
    • M Voss
    • B Wolff
    • N Savitskaia
    • H Ungefroren
    • W Deppert
    • W Schmiegel
    • H Kalthoff
    • M Naumann
  • View Affiliations

  • Published online on: January 1, 1999     https://doi.org/10.3892/ijo.14.1.93
  • Pages: 93-194
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Abstract

It is generally assumed that TGFbeta induces cell cycle arrest through the cooperative action of cell cycle inhibitors p15, p27 and p21. Here, we found that several pancreatic carcinoma cell lines exert TGFbeta-induced negative growth control in spite of the loss of p15 and p16 expression. In these cell lines, TGFbeta-induced growth control correlates with the upregulation of the p21 protein and active pRb expression. Conversely, cells without p21 and/or pRb expression are resistant to TGFbeta -induced growth inhibition. Moreover, overexpression of p21 in the p21-deficient cell line Panc Tu1 leads to growth arrest. Thus, TGFbeta-induced growth control correlates with p21 expression and pRb status independent of p15 and/or p16 expression.

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Jan 1999
Volume 14 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Voss M, Wolff B, Savitskaia N, Ungefroren H, Deppert W, Schmiegel W, Kalthoff H and Naumann M: TGFbeta-induced growth inhibition involves cell cycle inhibitor p21 and pRb independent from p15 expression.. Int J Oncol 14: 93-194, 1999
APA
Voss, M., Wolff, B., Savitskaia, N., Ungefroren, H., Deppert, W., Schmiegel, W. ... Naumann, M. (1999). TGFbeta-induced growth inhibition involves cell cycle inhibitor p21 and pRb independent from p15 expression.. International Journal of Oncology, 14, 93-194. https://doi.org/10.3892/ijo.14.1.93
MLA
Voss, M., Wolff, B., Savitskaia, N., Ungefroren, H., Deppert, W., Schmiegel, W., Kalthoff, H., Naumann, M."TGFbeta-induced growth inhibition involves cell cycle inhibitor p21 and pRb independent from p15 expression.". International Journal of Oncology 14.1 (1999): 93-194.
Chicago
Voss, M., Wolff, B., Savitskaia, N., Ungefroren, H., Deppert, W., Schmiegel, W., Kalthoff, H., Naumann, M."TGFbeta-induced growth inhibition involves cell cycle inhibitor p21 and pRb independent from p15 expression.". International Journal of Oncology 14, no. 1 (1999): 93-194. https://doi.org/10.3892/ijo.14.1.93