Prognostic markers in clinically localised prostate cancer.

  • Authors:
    • X Z Bai
    • J R Masters
    • N O'Donoghue
    • R Kirby
    • L X Pan
    • M Young
    • M Stafford
    • M C Parkinson
  • View Affiliations

  • Published online on: April 1, 1999     https://doi.org/10.3892/ijo.14.4.785
  • Pages: 785-876
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Abstract

The prognostic value of immunohistochemical staining of P53, BCL-2, p27kip1, PSA, AR and MIB-1 was compared with that of established prognostic variables (Gleason score, surgical margins, tumour volume) following radical prostatectomy. Five groups were selected: negative margins with stable serum PSA (n=11), negative margins with rising serum PSA (n=7), positive margins with stable serum PSA (n=7), positive margins with rising serum PSA (6) and patients with micrometastatic disease diagnosed in lymph nodes removed during radical prostatectomy (n=8). Gleason score and tumour volume were of prognostic significance and immunohistochemical staining for MIB-1 and BCL-2 showed added independent prognostic significance in multivariate analysis.

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Apr 1999
Volume 14 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Bai X, Masters J, O'Donoghue N, Kirby R, Pan L, Young M, Stafford M and Parkinson M: Prognostic markers in clinically localised prostate cancer.. Int J Oncol 14: 785-876, 1999
APA
Bai, X., Masters, J., O'Donoghue, N., Kirby, R., Pan, L., Young, M. ... Parkinson, M. (1999). Prognostic markers in clinically localised prostate cancer.. International Journal of Oncology, 14, 785-876. https://doi.org/10.3892/ijo.14.4.785
MLA
Bai, X., Masters, J., O'Donoghue, N., Kirby, R., Pan, L., Young, M., Stafford, M., Parkinson, M."Prognostic markers in clinically localised prostate cancer.". International Journal of Oncology 14.4 (1999): 785-876.
Chicago
Bai, X., Masters, J., O'Donoghue, N., Kirby, R., Pan, L., Young, M., Stafford, M., Parkinson, M."Prognostic markers in clinically localised prostate cancer.". International Journal of Oncology 14, no. 4 (1999): 785-876. https://doi.org/10.3892/ijo.14.4.785