Co-overexpression of p53 protein and epidermal growth factor receptor in human papillary thyroid carcinomas correlated with lymph node metastasis, tumor size and clinicopathologic stage.

  • Authors:
    • B K Chen
    • Y Ohtsuki
    • M Furihata
    • T Takeuchi
    • J Iwata
    • S B Liang
    • H Sonobe
  • View Affiliations

  • Published online on: November 1, 1999     https://doi.org/10.3892/ijo.15.5.893
  • Pages: 893-901
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Abstract

Expressions of p53 protein and epidermal growth factor receptor (EGFR) were immunohistochemically investigated in 111 patients with papillary thyroid carcinomas (PTC) in order to evaluate their co-expression in relation to lymph node metastases (LNM), tumor size and clinicopathologic stage. In PTC, positive staining for p53 in dewaxed sections was present in nuclei or cytoplasm, or in both, whereas surface linear or cytoplasmic staining for EGFR was observed with varying degrees of extent and intensity. Positive reaction (more than 10% of tumor cells positive) was observed in 65 cases (58. 5%) for p53, and in 87 cases (78.4%) for EGFR. A significant correlation was found between p53 protein and EGFR overexpressions (p<0.01). Notably, p53-positive cases always exhibited positive staining for EGFR. Forty-four patients (39.6%) exhibited concomitant LNM, most of whom had both p53 and EGFR expression in primary foci. Statistical analysis revealed that co-expression of p53 protein and EGFR was significantly correlated with LNM, tumor size and clinicopathologic stage, but no correlation was found between their co-expression and age or sex. Our findings suggest that overexpression of p53 protein or EGFR in PTC tends to be associated with a high frequency of LNM, increased tumor size and advanced clinicopathologic stage, and that co-expression of both p53 protein and EGFR may predispose to growth and progression of PTC. Our findings also suggest that p53 protein and EGFR expressions may be clinicopathologic and prognostic indicators of PTC.

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Nov 1999
Volume 15 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Chen B, Ohtsuki Y, Furihata M, Takeuchi T, Iwata J, Liang S and Sonobe H: Co-overexpression of p53 protein and epidermal growth factor receptor in human papillary thyroid carcinomas correlated with lymph node metastasis, tumor size and clinicopathologic stage.. Int J Oncol 15: 893-901, 1999
APA
Chen, B., Ohtsuki, Y., Furihata, M., Takeuchi, T., Iwata, J., Liang, S., & Sonobe, H. (1999). Co-overexpression of p53 protein and epidermal growth factor receptor in human papillary thyroid carcinomas correlated with lymph node metastasis, tumor size and clinicopathologic stage.. International Journal of Oncology, 15, 893-901. https://doi.org/10.3892/ijo.15.5.893
MLA
Chen, B., Ohtsuki, Y., Furihata, M., Takeuchi, T., Iwata, J., Liang, S., Sonobe, H."Co-overexpression of p53 protein and epidermal growth factor receptor in human papillary thyroid carcinomas correlated with lymph node metastasis, tumor size and clinicopathologic stage.". International Journal of Oncology 15.5 (1999): 893-901.
Chicago
Chen, B., Ohtsuki, Y., Furihata, M., Takeuchi, T., Iwata, J., Liang, S., Sonobe, H."Co-overexpression of p53 protein and epidermal growth factor receptor in human papillary thyroid carcinomas correlated with lymph node metastasis, tumor size and clinicopathologic stage.". International Journal of Oncology 15, no. 5 (1999): 893-901. https://doi.org/10.3892/ijo.15.5.893