Telomerase activity in non-small cell lung carcinomas correlates with smoking status.

  • Authors:
    • G Xinarianos
    • F M Scott
    • T Liloglou
    • W Prime
    • J Callaghan
    • J R Gosney
    • J K Field
  • View Affiliations

  • Published online on: November 1, 1999     https://doi.org/10.3892/ijo.15.5.961
  • Pages: 961-966
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Abstract

Human telomerase is a ribonucleoprotein DNA polymerase which maintains the telomeric region of human chromosomes and has been detected in all types of human cancer tested. We used the telomeric repeat amplification protocol (TRAP) assay to examine 71 non-small cell lung carcinomas (NSCLC) and their adjacent normal tissue. Telomerase activity was detected in 61 (86%) of the 71 NSCLC examined but not in any of the matched normal lung tissues. A significant correlation was found between the presence of telomerase activity and current smoking status at the time of diagnosis (p=0. 0076). In addition, a trend was found between telomerase activity and smoking exposure (p=0.06). Our findings demonstrate that telomerase activity is a common phenomenon in NSCLC cases but not in the normal lung. However, certain cases in former smokers may follow a telomerase independent pathway.

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Nov 1999
Volume 15 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Xinarianos G, Scott F, Liloglou T, Prime W, Callaghan J, Gosney J and Field J: Telomerase activity in non-small cell lung carcinomas correlates with smoking status.. Int J Oncol 15: 961-966, 1999
APA
Xinarianos, G., Scott, F., Liloglou, T., Prime, W., Callaghan, J., Gosney, J., & Field, J. (1999). Telomerase activity in non-small cell lung carcinomas correlates with smoking status.. International Journal of Oncology, 15, 961-966. https://doi.org/10.3892/ijo.15.5.961
MLA
Xinarianos, G., Scott, F., Liloglou, T., Prime, W., Callaghan, J., Gosney, J., Field, J."Telomerase activity in non-small cell lung carcinomas correlates with smoking status.". International Journal of Oncology 15.5 (1999): 961-966.
Chicago
Xinarianos, G., Scott, F., Liloglou, T., Prime, W., Callaghan, J., Gosney, J., Field, J."Telomerase activity in non-small cell lung carcinomas correlates with smoking status.". International Journal of Oncology 15, no. 5 (1999): 961-966. https://doi.org/10.3892/ijo.15.5.961