Expression of angiostatic factors in colorectal cancer.

  • Authors:
    • Y Yoshida
    • Y Oshika
    • Y Fukushima
    • T Tokunaga
    • H Hatanaka
    • H Kijima
    • H Yamazaki
    • Y Ueyama
    • N Tamaoki
    • S Miura
    • M Nakamura
  • View Affiliations

  • Published online on: December 1, 1999     https://doi.org/10.3892/ijo.15.6.1221
  • Pages: 1221-1226
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Abstract

Angiogenesis plays an important role in growth and proliferation of cancer. Various angiogenic and angiostatic factors regulate angiogenesis. We examined expression of genes encoding various angiostatic factors: thrombospondin 1 (TSP1), thrombospondin 2 (TSP2), brain-specific angiogenesis inhibitor 1 (BAI1) and angiopoietin 2 (AGP2) in 62 colorectal cancers and 40 samples of extraneoplastic colon mucosa. The expression of the angiostatic factors TSP2 and AGP2 were significantly increased in the cancerous mucosa as compared to these in extraneoplastic mucosa (o2 test; p<0. 0001, and Fisher's exact test; p<0.0001), while the increase in TSP1 expression was not significant. BAI1 expression was slightly decreased in the cancer tissue. These results suggested that specific types of angiostatic factors might have protective roles against cancer cell proliferation via dormancy due to hyponutrition caused by decreased vascularity.

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Dec 1999
Volume 15 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Yoshida Y, Oshika Y, Fukushima Y, Tokunaga T, Hatanaka H, Kijima H, Yamazaki H, Ueyama Y, Tamaoki N, Miura S, Miura S, et al: Expression of angiostatic factors in colorectal cancer.. Int J Oncol 15: 1221-1226, 1999
APA
Yoshida, Y., Oshika, Y., Fukushima, Y., Tokunaga, T., Hatanaka, H., Kijima, H. ... Nakamura, M. (1999). Expression of angiostatic factors in colorectal cancer.. International Journal of Oncology, 15, 1221-1226. https://doi.org/10.3892/ijo.15.6.1221
MLA
Yoshida, Y., Oshika, Y., Fukushima, Y., Tokunaga, T., Hatanaka, H., Kijima, H., Yamazaki, H., Ueyama, Y., Tamaoki, N., Miura, S., Nakamura, M."Expression of angiostatic factors in colorectal cancer.". International Journal of Oncology 15.6 (1999): 1221-1226.
Chicago
Yoshida, Y., Oshika, Y., Fukushima, Y., Tokunaga, T., Hatanaka, H., Kijima, H., Yamazaki, H., Ueyama, Y., Tamaoki, N., Miura, S., Nakamura, M."Expression of angiostatic factors in colorectal cancer.". International Journal of Oncology 15, no. 6 (1999): 1221-1226. https://doi.org/10.3892/ijo.15.6.1221