Suppression of metastasis by tissue inhibitor of metalloproteinase-1 in a newly established human oral squamous cell carcinoma cell line.

  • Authors:
    • M Nii
    • Y Kayada
    • K Yoshiga
    • K Takada
    • T Okamoto
    • K Yanagihara
  • View Affiliations

  • Published online on: January 1, 2000     https://doi.org/10.3892/ijo.16.1.119
  • Pages: 119-143
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Abstract

We have established a highly-metastatic cell line (designated as HNOS) and a non-metastatic cell line (designated as SAT) derived from human oral cavity squamous cell carcinoma (SCC). Both lines were transplantable in nude mice. The invasive activity through Matrigel-coated membrane of HNOS cells was also higher than that of SAT cells. mRNA of TIMP-1 was expressed in SAT cells but not in HNOS cells. Metastatic and invasive abilities were suppressed by the overexpression of TIMP-1 in HNOS cells. These results suggest that TIMP-1 may have an important role in inhibiting invasion and metastasis of human oral cavity SCC.

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Jan 2000
Volume 16 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Nii M, Kayada Y, Yoshiga K, Takada K, Okamoto T and Yanagihara K: Suppression of metastasis by tissue inhibitor of metalloproteinase-1 in a newly established human oral squamous cell carcinoma cell line.. Int J Oncol 16: 119-143, 2000
APA
Nii, M., Kayada, Y., Yoshiga, K., Takada, K., Okamoto, T., & Yanagihara, K. (2000). Suppression of metastasis by tissue inhibitor of metalloproteinase-1 in a newly established human oral squamous cell carcinoma cell line.. International Journal of Oncology, 16, 119-143. https://doi.org/10.3892/ijo.16.1.119
MLA
Nii, M., Kayada, Y., Yoshiga, K., Takada, K., Okamoto, T., Yanagihara, K."Suppression of metastasis by tissue inhibitor of metalloproteinase-1 in a newly established human oral squamous cell carcinoma cell line.". International Journal of Oncology 16.1 (2000): 119-143.
Chicago
Nii, M., Kayada, Y., Yoshiga, K., Takada, K., Okamoto, T., Yanagihara, K."Suppression of metastasis by tissue inhibitor of metalloproteinase-1 in a newly established human oral squamous cell carcinoma cell line.". International Journal of Oncology 16, no. 1 (2000): 119-143. https://doi.org/10.3892/ijo.16.1.119