Electrochemotherapy with bleomycin against colorectal carcinoma in a mouse model: evaluations of the dose and administration route of the drug and the electric field intensity.

  • Authors:
    • A Mitoro
    • S Kuriyama
    • H Tsujinoue
    • M Matsumoto
    • T Nakatani
    • H Fukui
  • View Affiliations

  • Published online on: January 1, 2000     https://doi.org/10.3892/ijo.16.1.97
  • Pages: 97-201
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Abstract

Effectiveness of electrochemotherapy against colorectal carcinoma (CRC) was evaluated in a mouse model. When mice with a subcutaneously established CRC tumor were administered intratumorally, intravenously or intraperitoneally with bleomycin (BLM) ranging from 1/50 to 1/2 of the 50% lethal dose, significant suppression of tumor development and even some cures were observed. When various electric field intensities ranging from 500 to 2,000 V/cm were applied for electrochemotherapy with BLM, all treatment protocols were similarly effective. Furthermore, when electrochemotherapy with the lowest dose of BLM and the lowest electric field intensity was repeated, complete cures of CRC were achieved in all animals.

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Jan 2000
Volume 16 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Mitoro A, Kuriyama S, Tsujinoue H, Matsumoto M, Nakatani T and Fukui H: Electrochemotherapy with bleomycin against colorectal carcinoma in a mouse model: evaluations of the dose and administration route of the drug and the electric field intensity.. Int J Oncol 16: 97-201, 2000
APA
Mitoro, A., Kuriyama, S., Tsujinoue, H., Matsumoto, M., Nakatani, T., & Fukui, H. (2000). Electrochemotherapy with bleomycin against colorectal carcinoma in a mouse model: evaluations of the dose and administration route of the drug and the electric field intensity.. International Journal of Oncology, 16, 97-201. https://doi.org/10.3892/ijo.16.1.97
MLA
Mitoro, A., Kuriyama, S., Tsujinoue, H., Matsumoto, M., Nakatani, T., Fukui, H."Electrochemotherapy with bleomycin against colorectal carcinoma in a mouse model: evaluations of the dose and administration route of the drug and the electric field intensity.". International Journal of Oncology 16.1 (2000): 97-201.
Chicago
Mitoro, A., Kuriyama, S., Tsujinoue, H., Matsumoto, M., Nakatani, T., Fukui, H."Electrochemotherapy with bleomycin against colorectal carcinoma in a mouse model: evaluations of the dose and administration route of the drug and the electric field intensity.". International Journal of Oncology 16, no. 1 (2000): 97-201. https://doi.org/10.3892/ijo.16.1.97