Nuclear accumulation of p53 protein and apoptosis induced by various anticancer agents, u.v.-irradiation and heat shock in primary normal human skin fibroblasts.

  • Authors:
    • S Chikayama
    • T Sugano
    • Y Takahashi
    • M Ikeda
    • S Kimura
    • Y Kobayashi
    • M Kondo
  • View Affiliations

  • Published online on: June 1, 2000     https://doi.org/10.3892/ijo.16.6.1117
  • Pages: 1117-1141
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Abstract

Relationship between nuclear accumulation of p53 protein and apoptosis induced by both DNA damaging agents (ultraviolet-irradiation and anticancer agents) and heat shock in normal human skin fibroblasts was investigated. Nuclear accumulation of p53 protein and apoptosis were induced dose-dependently by u.v. -irradiation and anticancer agents. Regarding heat shock treatment, intensive nuclear accumulation of p53 protein was induced by treatment at 43 degrees C for 45 min, but, apoptotic cells were never detected. These results indicated that accumulation of p53 protein and apoptosis induced by DNA damaging agents were considered to have a close relationship and the functions of induced p53 protein are different depending on the stimulating factor.

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Jun 2000
Volume 16 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Chikayama S, Sugano T, Takahashi Y, Ikeda M, Kimura S, Kobayashi Y and Kondo M: Nuclear accumulation of p53 protein and apoptosis induced by various anticancer agents, u.v.-irradiation and heat shock in primary normal human skin fibroblasts.. Int J Oncol 16: 1117-1141, 2000
APA
Chikayama, S., Sugano, T., Takahashi, Y., Ikeda, M., Kimura, S., Kobayashi, Y., & Kondo, M. (2000). Nuclear accumulation of p53 protein and apoptosis induced by various anticancer agents, u.v.-irradiation and heat shock in primary normal human skin fibroblasts.. International Journal of Oncology, 16, 1117-1141. https://doi.org/10.3892/ijo.16.6.1117
MLA
Chikayama, S., Sugano, T., Takahashi, Y., Ikeda, M., Kimura, S., Kobayashi, Y., Kondo, M."Nuclear accumulation of p53 protein and apoptosis induced by various anticancer agents, u.v.-irradiation and heat shock in primary normal human skin fibroblasts.". International Journal of Oncology 16.6 (2000): 1117-1141.
Chicago
Chikayama, S., Sugano, T., Takahashi, Y., Ikeda, M., Kimura, S., Kobayashi, Y., Kondo, M."Nuclear accumulation of p53 protein and apoptosis induced by various anticancer agents, u.v.-irradiation and heat shock in primary normal human skin fibroblasts.". International Journal of Oncology 16, no. 6 (2000): 1117-1141. https://doi.org/10.3892/ijo.16.6.1117