Autocrine motility factor receptor expression associates with tumor progression in thymoma.

  • Authors:
    • Y Ohta
    • H Minato
    • Y Tanaka
    • T Go
    • M Oda
    • Y Watanabe
  • View Affiliations

  • Published online on: August 1, 2000     https://doi.org/10.3892/ijo.17.2.259
  • Pages: 259-323
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Abstract

We assessed the autocrine motility factor receptor (AMFR/gp78) expression in thymoma. AMFR/gp78 antigen was identified in tumor cells in 16 out of 51 (31.4%) thymomas. The AMFR/gp78 expression was closely associated with the stage (I/II vs. III/IV, p<0.0001), pathological subtypes (epithelial vs. other types, p=0.0214), and enhanced expression of alpha-smooth-muscle actin within stroma (p<0. 0001). The outcome of the patients with AMFR/gp78 expression was significantly worse than for those without it (p<0.01). All initial tumors with recurrence expressed AMFR/gp78. The AMFR/gp78 appears to be involved in tumor progression in thymoma.

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Aug 2000
Volume 17 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Ohta Y, Minato H, Tanaka Y, Go T, Oda M and Watanabe Y: Autocrine motility factor receptor expression associates with tumor progression in thymoma.. Int J Oncol 17: 259-323, 2000
APA
Ohta, Y., Minato, H., Tanaka, Y., Go, T., Oda, M., & Watanabe, Y. (2000). Autocrine motility factor receptor expression associates with tumor progression in thymoma.. International Journal of Oncology, 17, 259-323. https://doi.org/10.3892/ijo.17.2.259
MLA
Ohta, Y., Minato, H., Tanaka, Y., Go, T., Oda, M., Watanabe, Y."Autocrine motility factor receptor expression associates with tumor progression in thymoma.". International Journal of Oncology 17.2 (2000): 259-323.
Chicago
Ohta, Y., Minato, H., Tanaka, Y., Go, T., Oda, M., Watanabe, Y."Autocrine motility factor receptor expression associates with tumor progression in thymoma.". International Journal of Oncology 17, no. 2 (2000): 259-323. https://doi.org/10.3892/ijo.17.2.259