Indomethacin and telomerase activity in tumor growth retardation

  • Authors:
    • Christina Lonnroth
    • Marianne Andersson
    • Kent Lundholm
  • View Affiliations

  • Published online on: May 1, 2001     https://doi.org/10.3892/ijo.18.5.929
  • Pages: 929-937
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Abstract

It is well-recognized that cycloogygenase inhibitors attenuate tumor growth in tumor models, although underlying mechanisms are unclear. In the present study we report that indomethacin retards MCG-101 tumor growth on mice by induction of apoptosis/necrosis and inhibits telomere elongation. The inhibition of telomerase activity by NSAIDs (indomethacin, mobic, sulindac sulfone, suramin) was, however, not a universal finding, since a mouse melanoma (K1735-M2) did not respond. By contrast, a human cell line of colon carcinoma origin (HT-29), responded by both retarded growth and telomerase activity despite a low intrinsic production of prostaglandins, mainly PGE2. Therefore, it is not likely that indomethacin inhibition of tumor growth and telomere elongation is directly related to Cox-1/Cox-2 activities in tumor cells. Also, NSAIDs at 25 μM (sulindac sulfone) decreased growth and telomerase activity in MCG-101 cells, without any effects on PGE2 production, while ibuprofen reduced PGE2 production but had no effect on growth or telomerase activity. Our results demonstrate that cyclooxygenase inhibitors can retard tumor growth both in murine tumors and in human tumor cells by inhibition of telomerase activity in addition to previously recognized mechanisms as induction of apoptosis, inhibition of cell proliferation, influence on the expression of growth factors around growing tumors and attenuation of neoangiogenesis.

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May 2001
Volume 18 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Lonnroth C, Andersson M and Lundholm K: Indomethacin and telomerase activity in tumor growth retardation. Int J Oncol 18: 929-937, 2001
APA
Lonnroth, C., Andersson, M., & Lundholm, K. (2001). Indomethacin and telomerase activity in tumor growth retardation. International Journal of Oncology, 18, 929-937. https://doi.org/10.3892/ijo.18.5.929
MLA
Lonnroth, C., Andersson, M., Lundholm, K."Indomethacin and telomerase activity in tumor growth retardation". International Journal of Oncology 18.5 (2001): 929-937.
Chicago
Lonnroth, C., Andersson, M., Lundholm, K."Indomethacin and telomerase activity in tumor growth retardation". International Journal of Oncology 18, no. 5 (2001): 929-937. https://doi.org/10.3892/ijo.18.5.929