TRANSFECTION OF THE MULLERIAN INHIBITING SUBSTANCE GENE INHIBITS LOCAL AND METASTATIC TUMOR-GROWTH

  • Authors:
    • JF BOVERI
    • RL PARRY
    • WK RUFFIN
    • ML GUSTAFSON
    • KW LEE
    • WW HE
    • PK DONAHOE
  • View Affiliations

  • Published online on: February 1, 1993     https://doi.org/10.3892/ijo.2.2.135
  • Pages: 135-143
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Mullerian Inhibiting Substance (MIS), a gonadal growth factor important in sexual differentiation, has antiproliferative activity against several human carcinoma cell lines. In this study, we examine the effect of MIS-transfection on the growth characteristics of Chinese hamster ovary (CHO) and human ocular melanoma (OM431) cells, compared to wild-type lines and a CHO line transfected with a noncleavable, inactive MIS mutant. MIS-transfection inhibited proliferation of CHO cells in double-layer agarose, tumor spheroid, and murine subrenal capsule assays, as well as growth of CHO and OM431 cells in pulmonary metastasis studies. These results anticipate further study of targeted gene therapy of certain human tumors with MIS gene constructs.

Related Articles

Journal Cover

February 1993
Volume 2 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
BOVERI J, PARRY R, RUFFIN W, GUSTAFSON M, LEE K, HE W and DONAHOE P: TRANSFECTION OF THE MULLERIAN INHIBITING SUBSTANCE GENE INHIBITS LOCAL AND METASTATIC TUMOR-GROWTH. Int J Oncol 2: 135-143, 1993
APA
BOVERI, J., PARRY, R., RUFFIN, W., GUSTAFSON, M., LEE, K., HE, W., & DONAHOE, P. (1993). TRANSFECTION OF THE MULLERIAN INHIBITING SUBSTANCE GENE INHIBITS LOCAL AND METASTATIC TUMOR-GROWTH. International Journal of Oncology, 2, 135-143. https://doi.org/10.3892/ijo.2.2.135
MLA
BOVERI, J., PARRY, R., RUFFIN, W., GUSTAFSON, M., LEE, K., HE, W., DONAHOE, P."TRANSFECTION OF THE MULLERIAN INHIBITING SUBSTANCE GENE INHIBITS LOCAL AND METASTATIC TUMOR-GROWTH". International Journal of Oncology 2.2 (1993): 135-143.
Chicago
BOVERI, J., PARRY, R., RUFFIN, W., GUSTAFSON, M., LEE, K., HE, W., DONAHOE, P."TRANSFECTION OF THE MULLERIAN INHIBITING SUBSTANCE GENE INHIBITS LOCAL AND METASTATIC TUMOR-GROWTH". International Journal of Oncology 2, no. 2 (1993): 135-143. https://doi.org/10.3892/ijo.2.2.135