A MODEL ON THE ORIGIN AND EVOLUTION OF DNA ANEUPLOIDY

  • Authors:
    • W GIARETTI
  • View Affiliations

  • Published online on: February 1, 1993     https://doi.org/10.3892/ijo.2.2.165
  • Pages: 165-171
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Abstract

A model on the origin and evolution of DNA aneuploidy based on a postulated mechanism of DNA asymmetrical cell division is presented. Asymmetry in cell division would be at the origin of hypodiploid cells in the near-diploid region. Tetraploidization of a hypodiploid cell would be one of the main routes by which advanced tumors may evolve to aneuploidy in the near-triploid region. The model is supported by nuclear DNA content data obtained by high resolution flow cytometry from fresh/frozen material during the colorectal tumor progression.

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February 1993
Volume 2 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
GIARETTI W: A MODEL ON THE ORIGIN AND EVOLUTION OF DNA ANEUPLOIDY. Int J Oncol 2: 165-171, 1993
APA
GIARETTI, W. (1993). A MODEL ON THE ORIGIN AND EVOLUTION OF DNA ANEUPLOIDY. International Journal of Oncology, 2, 165-171. https://doi.org/10.3892/ijo.2.2.165
MLA
GIARETTI, W."A MODEL ON THE ORIGIN AND EVOLUTION OF DNA ANEUPLOIDY". International Journal of Oncology 2.2 (1993): 165-171.
Chicago
GIARETTI, W."A MODEL ON THE ORIGIN AND EVOLUTION OF DNA ANEUPLOIDY". International Journal of Oncology 2, no. 2 (1993): 165-171. https://doi.org/10.3892/ijo.2.2.165