EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH FACTOR-ALPHA IN HUMAN MENINGIOMAS

  • Authors:
    • SH TORP
    • G UNSGAARD
    • A DALEN
  • View Affiliations

  • Published online on: May 1, 1993     https://doi.org/10.3892/ijo.2.5.763
  • Pages: 763-765
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Abstract

Recently we have shown that human meningiomas overexpress epidermal growth factor receptor (EGFR) (Torp SH et al APMIS 100: 797-802, 1992). We therefore wanted to examine these tumours for the expression of the EGFR ligands epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha). Normal human meningeal tissues were used as controls. Immunohistochemistry (IH) and radioimmunoassay (RIA) demonstrated the presence of EGF and/or TGF-alpha. immunoreactivity in sixteen of nineteen meningiomas. By means of RIA detectable amount of TGF-alpha was also recorded in normal leptomeninges. Discrepancies between IH and RIA were noted and are discussed. Our findings suggest that EGFR/EGF/TGF-alpha play a role in growth regulatory mechanisms in human meningiomas.

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May 1993
Volume 2 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
TORP S, UNSGAARD G and DALEN A: EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH FACTOR-ALPHA IN HUMAN MENINGIOMAS. Int J Oncol 2: 763-765, 1993
APA
TORP, S., UNSGAARD, G., & DALEN, A. (1993). EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH FACTOR-ALPHA IN HUMAN MENINGIOMAS. International Journal of Oncology, 2, 763-765. https://doi.org/10.3892/ijo.2.5.763
MLA
TORP, S., UNSGAARD, G., DALEN, A."EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH FACTOR-ALPHA IN HUMAN MENINGIOMAS". International Journal of Oncology 2.5 (1993): 763-765.
Chicago
TORP, S., UNSGAARD, G., DALEN, A."EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH FACTOR-ALPHA IN HUMAN MENINGIOMAS". International Journal of Oncology 2, no. 5 (1993): 763-765. https://doi.org/10.3892/ijo.2.5.763