LOSS OF HETEROZYGOSITY - ORIGIN OR RESULT OF CARCINOGENESIS

  • Authors:
    • M CHIGIRA
    • S ARITA
    • H WATANABE
  • View Affiliations

  • Published online on: June 1, 1993     https://doi.org/10.3892/ijo.2.6.931
  • Pages: 931-935
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Abstract

Loss of heterozygosity has recently been discussed in the field of carcinogenesis, since loss of tumor suppressor gene has been believed to play a key role in carcinogenesis. However, recent evidence suggests that the loss of heterozygosity is a non-specific process in tumor progression rather than a specific process of carcinogenesis. Most loss of heterozygosity demonstrated by RFLP does not show the loss of tumor suppressors in a strict sense. We have to change our concept that loss of heterozygosity exclusively induces malignant phenotypes in cells. A likely explanation is that loss of heterozygosity is a general and rather stochastic process in tumor progression, and is due to loss of DNA replication fidelity. Detection of loss of heterozygosity without functional analysis may only accumulate meaningless data in tumor biology.

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June 1993
Volume 2 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
CHIGIRA M, ARITA S and WATANABE H: LOSS OF HETEROZYGOSITY - ORIGIN OR RESULT OF CARCINOGENESIS. Int J Oncol 2: 931-935, 1993
APA
CHIGIRA, M., ARITA, S., & WATANABE, H. (1993). LOSS OF HETEROZYGOSITY - ORIGIN OR RESULT OF CARCINOGENESIS. International Journal of Oncology, 2, 931-935. https://doi.org/10.3892/ijo.2.6.931
MLA
CHIGIRA, M., ARITA, S., WATANABE, H."LOSS OF HETEROZYGOSITY - ORIGIN OR RESULT OF CARCINOGENESIS". International Journal of Oncology 2.6 (1993): 931-935.
Chicago
CHIGIRA, M., ARITA, S., WATANABE, H."LOSS OF HETEROZYGOSITY - ORIGIN OR RESULT OF CARCINOGENESIS". International Journal of Oncology 2, no. 6 (1993): 931-935. https://doi.org/10.3892/ijo.2.6.931