NO-releasing NSAIDs and colon cancer chemoprevention: A promising novel approach (Review)

  • Authors:
    • Basil Rigas
    • Jennie L. Williams
  • View Affiliations

  • Published online on: May 1, 2002     https://doi.org/10.3892/ijo.20.5.885
  • Pages: 885-890
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The chemoprevention of colon cancer, the second leading cause of cancer-related deaths in the United States, has been pursued actively during the last two decades. Methodological problems and those stemming from the available agents per se have constrained this difficult task; to some extent, these problems persist to date. That NSAIDs decrease the incidence of and mortality from colon cancer has been a major advance in chemoprevention. These compounds are, however, limited by their significant side effects. NO-releasing NSAIDs (NO-NSAIDs) are a novel class of compounds, synthesized to overcome the limitations of NSAIDs. In general, they appear safer and much more effective than their traditional counterparts. We review their structural features, metabolism and pharmacological actions. In vitro and in vivo studies indicate that they are much more effective than traditional NSAIDs in modulating colonocyte kinetics and the formation of premalignant colon lesions. Their mechanism of action is complex and not fully understood, including modulation of NO synthesis, signaling mediated via NF-κB and likely other pathways. Current early findings indicate that NO-NSAIDs may play a highly promising role in the chemoprevention of colon cancer.

Related Articles

Journal Cover

May 2002
Volume 20 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Rigas B and Rigas B: NO-releasing NSAIDs and colon cancer chemoprevention: A promising novel approach (Review). Int J Oncol 20: 885-890, 2002
APA
Rigas, B., & Rigas, B. (2002). NO-releasing NSAIDs and colon cancer chemoprevention: A promising novel approach (Review). International Journal of Oncology, 20, 885-890. https://doi.org/10.3892/ijo.20.5.885
MLA
Rigas, B., Williams, J. L."NO-releasing NSAIDs and colon cancer chemoprevention: A promising novel approach (Review)". International Journal of Oncology 20.5 (2002): 885-890.
Chicago
Rigas, B., Williams, J. L."NO-releasing NSAIDs and colon cancer chemoprevention: A promising novel approach (Review)". International Journal of Oncology 20, no. 5 (2002): 885-890. https://doi.org/10.3892/ijo.20.5.885