Prognostic significance of S100A4 expression in gallbladder cancer

  • Authors:
    • Tetsu Nakamura
    • Tetsuo Ajiki
    • Shinichi Murao
    • Takashi Kamigaki
    • Sakan Maeda
    • Yonson Ku
    • Yoshikazu Kuroda
  • View Affiliations

  • Published online on: May 1, 2002     https://doi.org/10.3892/ijo.20.5.937
  • Pages: 937-941
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Abstract

The calcium-binding protein S100A4 has been characterized as a metastasis-inducing molecule, and regulates cell motility and invasiveness of cancer cells. In order to clarify the significance of the expression of S100A4 as a prognostic factor in gallbladder cancer, S100A4 expression in resected gallbladder cancers were examined using an immunohistochemical staining technique. The relationship between S100A4 expression and clinicopathological factors including prognosis were evaluated. Twenty-five of 60 cases (42%) demonstrated positive staining for S100A4. There was no statistically significant association between S100A4 and histological grade, T, N, M factor, presence of stone, or stage. Kaplan-Meier method showed the 5-year survival rate of the group staining positive for S100A4 (31.5%) to be statistically poorer than that of the group staining negative for S100A4 (78.2%). Also in T2 cases, the 5-year survival rate of the group staining positive for S100A4 (57.1%) was statistically poorer than that of the group staining negative for S100A4 (83.3%). On univariate analysis, positive staining for S100A4 was a significant prognostic factor, and the hazard ratio was 4.05. On multivariate analysis, positive staining for S100A4 is also a significant predictor of prognosis second to T factor. These results indicate that positive staining for S100A4 is useful in assessing the prognosis of patients with gallbladder cancer as well as TNM factors.

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May 2002
Volume 20 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Nakamura T, Ajiki T, Murao S, Kamigaki T, Maeda S, Ku Y and Kuroda Y: Prognostic significance of S100A4 expression in gallbladder cancer. Int J Oncol 20: 937-941, 2002
APA
Nakamura, T., Ajiki, T., Murao, S., Kamigaki, T., Maeda, S., Ku, Y., & Kuroda, Y. (2002). Prognostic significance of S100A4 expression in gallbladder cancer. International Journal of Oncology, 20, 937-941. https://doi.org/10.3892/ijo.20.5.937
MLA
Nakamura, T., Ajiki, T., Murao, S., Kamigaki, T., Maeda, S., Ku, Y., Kuroda, Y."Prognostic significance of S100A4 expression in gallbladder cancer". International Journal of Oncology 20.5 (2002): 937-941.
Chicago
Nakamura, T., Ajiki, T., Murao, S., Kamigaki, T., Maeda, S., Ku, Y., Kuroda, Y."Prognostic significance of S100A4 expression in gallbladder cancer". International Journal of Oncology 20, no. 5 (2002): 937-941. https://doi.org/10.3892/ijo.20.5.937