Inhibition of fibroblast growth factors by green tea

  • Authors:
    • Maryam R. Sartippour
    • David Heber
    • Liping Zhang
    • Perrin Beatty
    • David Elashoff
    • Robert Elashoff
    • Vay Liang Go
    • Mai N. Brooks
  • View Affiliations

  • Published online on: September 1, 2002     https://doi.org/10.3892/ijo.21.3.487
  • Pages: 487-491
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Abstract

Investigators have shown that green tea may decrease the risk of cancer. It is widely accepted that the main active component of green tea is EGCG (epigallocatechin-3-gallate). In our previous study, we examined the effect of green tea on breast cancer growth and endothelial cells both in in vitro assays and in animal models. Our data show that both mixed green tea extract (GTE) as well as its individual catechin components are effective in inhibiting breast cancer and endothelial cell proliferation in vitro, and that GTE suppresses breast cancer xenograft size and decreases the tumor blood vessel density in vivo. In the present study, we further demonstrate that 40 μg/ml GTE or EGCG can decrease the levels of the angiogenic factor bFGF (basic fibroblast growth factor) levels in the cells. This phenomenon is observed in both human umbilical vein endothelial cells (HUVECs) and in human breast cancer cells MDA-MB231. This effect is dose dependent. Furthermore, GTE and EGCG decrease the transcript levels of bFGF and aFGF (acidic fibroblast growth factor) in HUVECs and MDA-MB231 cells. Our findings suggest that the inhibition of the angiogenic fibroblast growth factors could account for one of the mechanisms of green tea's actions. Since cancer is angiogenesis dependent, this may partially explain the antineoplastic effects associated with green tea consumption.

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September 2002
Volume 21 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Sartippour MR, Heber D, Zhang L, Beatty P, Elashoff D, Elashoff R, Go VL and Brooks MN: Inhibition of fibroblast growth factors by green tea. Int J Oncol 21: 487-491, 2002
APA
Sartippour, M.R., Heber, D., Zhang, L., Beatty, P., Elashoff, D., Elashoff, R. ... Brooks, M.N. (2002). Inhibition of fibroblast growth factors by green tea. International Journal of Oncology, 21, 487-491. https://doi.org/10.3892/ijo.21.3.487
MLA
Sartippour, M. R., Heber, D., Zhang, L., Beatty, P., Elashoff, D., Elashoff, R., Go, V. L., Brooks, M. N."Inhibition of fibroblast growth factors by green tea". International Journal of Oncology 21.3 (2002): 487-491.
Chicago
Sartippour, M. R., Heber, D., Zhang, L., Beatty, P., Elashoff, D., Elashoff, R., Go, V. L., Brooks, M. N."Inhibition of fibroblast growth factors by green tea". International Journal of Oncology 21, no. 3 (2002): 487-491. https://doi.org/10.3892/ijo.21.3.487