The homeobox gene BARX2 can modulate cisplatin sensitivity in human epithelial ovarian cancer

  • Authors:
    • Grant C. Sellar
    • Karen P. Watt
    • Li Li
    • Barry D. Nelkin
    • Genevieve J. Rabiasz
    • David J. Porteous
    • John F. Smyth
    • Hani Gabra
  • View Affiliations

  • Published online on: November 1, 2002     https://doi.org/10.3892/ijo.21.5.929
  • Pages: 929-933
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Abstract

Epithelial ovarian cancer (EOC) is the most common cause of death from gynaecological malignancy. Resistance to platinum chemotherapy is a major reason for treatment failure and poor prognosis. The human homeobox gene BARX2 is located within a minimal region at 11q25 that is associated with frequent loss of heterozygosity (LOH) and adverse survival in EOC. BARX2 is a transcription factor known to regulate transcription of specific cell adhesion molecules in the mouse. We have previously shown that BARX2 expression is low in clear cell/endometrioid and high in serous adenocarcinomas of the ovary, histologic variants that are less and more sensitive, respectively to platinum chemotherapy. The aim of this study was to define whether BARX2 could modulate sensitivity to cisplatin in human epithelial ovarian cancer. In two cell line series sequentially derived from ovarian cancer patients pre- and post-cisplatin chemotherapy, BARX2 expression was downregulated in the cell lines established upon tumor recurrence after platinum therapy. Transfection of BARX2 into a platinum resistant cell line significantly reversed cisplatin resistance compared with its isogenic platinum sensitive parent, in both growth inhibition and clonogenic assays. Taken together, our data demonstrate that the homeobox gene BARX2 may be a biological factor involved in determining sensitivity or resistance to the cytotoxic effects of cisplatin.

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November 2002
Volume 21 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Sellar GC, Watt KP, Li L, Nelkin BD, Rabiasz GJ, Porteous DJ, Smyth JF and Gabra H: The homeobox gene BARX2 can modulate cisplatin sensitivity in human epithelial ovarian cancer. Int J Oncol 21: 929-933, 2002
APA
Sellar, G.C., Watt, K.P., Li, L., Nelkin, B.D., Rabiasz, G.J., Porteous, D.J. ... Gabra, H. (2002). The homeobox gene BARX2 can modulate cisplatin sensitivity in human epithelial ovarian cancer. International Journal of Oncology, 21, 929-933. https://doi.org/10.3892/ijo.21.5.929
MLA
Sellar, G. C., Watt, K. P., Li, L., Nelkin, B. D., Rabiasz, G. J., Porteous, D. J., Smyth, J. F., Gabra, H."The homeobox gene BARX2 can modulate cisplatin sensitivity in human epithelial ovarian cancer". International Journal of Oncology 21.5 (2002): 929-933.
Chicago
Sellar, G. C., Watt, K. P., Li, L., Nelkin, B. D., Rabiasz, G. J., Porteous, D. J., Smyth, J. F., Gabra, H."The homeobox gene BARX2 can modulate cisplatin sensitivity in human epithelial ovarian cancer". International Journal of Oncology 21, no. 5 (2002): 929-933. https://doi.org/10.3892/ijo.21.5.929