Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: An index of malignancy in astrocytomas

  • Authors:
    • Fumio Yamaguchi
    • Richard S. Morrison
    • Nicholas K. Gonatas
    • Hiroshi Takahashi
    • Yuichi Sugisaki
    • Akira Teramoto
  • View Affiliations

  • Published online on: May 1, 2003     https://doi.org/10.3892/ijo.22.5.1045
  • Pages: 1045-1049
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Malignant astrocytomas are highly invasive, vascular neoplasms that comprise the majority of nervous system tumors in humans. A strong association has previously been made between malignancy in human astrocytic tumors and increased expression of certain fibroblast growth factor (FGF) family members. MG-160 is an intrinsic type I cysteine-rich membrane sialoglycoprotein that resides in the medial cisternae of the Golgi apparatus, highly homologous to CFR, chicken fibroblast growth factor receptor, and ESL-1, E-selectin ligand. MG-160 binds fibroblast growth factors (FGFs) and may be involved in the intracellular trafficking of FGFs and the regulation of cellular response to FGFs. In the present study MG-160 expression was evaluated in human brain tumors exhibiting varying degrees of malignancy. At the mRNA level MG-160 expression was inversely correlated with the histological grade of astrocytomas such that high levels of MG-160 were observed in low-grade astrocytomas and low levels in malignant astrocytomas. This differential expression of MG-160 mRNA was verified at the protein level using immunohistochemistry. Grade II astrocytomas displayed consistent and intense staining for MG-160 as seen in normal brain. In contrast to the lower grade tumors, grade IV astrocytomas exhibited variable and weaker expression of MG-160. Our results suggest that, MG-160 may participate in malignant progression in astrocytomas. In addition, other brain tumors and human astrocytoma cell lines were characterized for MG-160 expression.

Related Articles

Journal Cover

May 2003
Volume 22 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yamaguchi F, Morrison RS, Gonatas NK, Takahashi H, Sugisaki Y and Teramoto A: Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: An index of malignancy in astrocytomas. Int J Oncol 22: 1045-1049, 2003
APA
Yamaguchi, F., Morrison, R.S., Gonatas, N.K., Takahashi, H., Sugisaki, Y., & Teramoto, A. (2003). Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: An index of malignancy in astrocytomas. International Journal of Oncology, 22, 1045-1049. https://doi.org/10.3892/ijo.22.5.1045
MLA
Yamaguchi, F., Morrison, R. S., Gonatas, N. K., Takahashi, H., Sugisaki, Y., Teramoto, A."Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: An index of malignancy in astrocytomas". International Journal of Oncology 22.5 (2003): 1045-1049.
Chicago
Yamaguchi, F., Morrison, R. S., Gonatas, N. K., Takahashi, H., Sugisaki, Y., Teramoto, A."Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: An index of malignancy in astrocytomas". International Journal of Oncology 22, no. 5 (2003): 1045-1049. https://doi.org/10.3892/ijo.22.5.1045