Inositol-specific phospholipase C in low and fast proliferating hepatoma cell lines

  • Authors:
    • P. Santi
    • L. Solimando
    • N. Zini
    • S. Santi
    • M. Riccio
    • L. Guidotti
  • View Affiliations

  • Published online on: May 1, 2003     https://doi.org/10.3892/ijo.22.5.1147
  • Pages: 1147-1153
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Abstract

Inositol lipid cycle, among the pletora of signalling events, is directly involved in cell growth. It is located both in the cytoplasm and in the nucleus. Disturbances may cause uncontrolled proliferation of the cell and ultimately cancer. The phosphatidyl inositol phospolipase C (PLC) is a key enzyme in the hydrolysis of polyphosphoinositides (PIs) and could be differently involved in the normal and pathological cell growth. We report immunochemical and immunocytochemical demonstrations that the PLC isoforms are present in both cytoplasmic and nuclear compartments of low and fast proliferating hepatoma cells. The PLC activity is increased in fast proliferating cells, in which PLC δ1 and to a greater extent PLC δ4 are more expressed at cytosolic level, suggesting an involvement of PI specific PLCs in the progression of cell cycle and in the control of cell proliferation and possibly of neoplastic cell growth.

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May 2003
Volume 22 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Santi P, Solimando L, Zini N, Santi S, Riccio M and Guidotti L: Inositol-specific phospholipase C in low and fast proliferating hepatoma cell lines. Int J Oncol 22: 1147-1153, 2003
APA
Santi, P., Solimando, L., Zini, N., Santi, S., Riccio, M., & Guidotti, L. (2003). Inositol-specific phospholipase C in low and fast proliferating hepatoma cell lines. International Journal of Oncology, 22, 1147-1153. https://doi.org/10.3892/ijo.22.5.1147
MLA
Santi, P., Solimando, L., Zini, N., Santi, S., Riccio, M., Guidotti, L."Inositol-specific phospholipase C in low and fast proliferating hepatoma cell lines". International Journal of Oncology 22.5 (2003): 1147-1153.
Chicago
Santi, P., Solimando, L., Zini, N., Santi, S., Riccio, M., Guidotti, L."Inositol-specific phospholipase C in low and fast proliferating hepatoma cell lines". International Journal of Oncology 22, no. 5 (2003): 1147-1153. https://doi.org/10.3892/ijo.22.5.1147