Correlation of a single nucleotide polymorphism in the E-cadherin gene promoter with tumorigenesis and progression of gastric carcinoma in Japan

  • Authors:
    • Kazuya Kuraoka
    • Naohide Oue
    • Hiroshi Yokozaki
    • Yasuhiko Kitadai
    • Reiko Ito
    • Hirofumi Nakayama
    • Wataru Yasui
  • View Affiliations

  • Published online on: August 1, 2003     https://doi.org/10.3892/ijo.23.2.421
  • Pages: 421-427
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Abstract

A C/A single nucleotide polymorphism (SNP) in the E-cadherin gene promoter has been shown to affect transcriptional efficiency in vitro. In this study, we analyzed the C/A SNP in 106 gastric carcinoma cases and 90 cancer-free controls compared with clinicopathological parameters. The genotype of C/C, C/A, and A/A was found in 61 (58%), 34 (32%) and 11 (10%) of 106 gastric carcinoma cases and in 32 (36%), 52 (58%) and 6 (6%) of 90 cancer-free controls, respectively. The genotype of C/C was significantly more frequent in gastric carcinoma cases than in cancer-free controls (p<0.05). The E-cadherin protein expression level in non-neoplastic gastric mucosa was higher in the C/C genotype than in the C/A. In gastric carcinoma cases, the genotype of C/C was significantly more frequent in the cases of poorly differentiated adenocarcinoma (31/44; 70%) than in well differentiated type (30/62; 48%). The C/C genotype was also significantly more frequent in the cases with deep invasion (51/74; 69%) and with lymph node metastasis (38/54; 70%) than in those confined superficially (10/32; 31%) and without lymph node metastasis (23/52; 44%), respectively (p<0.05). These results suggest that the C/A SNP in the E-cadherin promoter may be a good marker for malignancy of gastric carcinomas.

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August 2003
Volume 23 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kuraoka K, Oue N, Yokozaki H, Kitadai Y, Ito R, Nakayama H and Yasui W: Correlation of a single nucleotide polymorphism in the E-cadherin gene promoter with tumorigenesis and progression of gastric carcinoma in Japan. Int J Oncol 23: 421-427, 2003
APA
Kuraoka, K., Oue, N., Yokozaki, H., Kitadai, Y., Ito, R., Nakayama, H., & Yasui, W. (2003). Correlation of a single nucleotide polymorphism in the E-cadherin gene promoter with tumorigenesis and progression of gastric carcinoma in Japan. International Journal of Oncology, 23, 421-427. https://doi.org/10.3892/ijo.23.2.421
MLA
Kuraoka, K., Oue, N., Yokozaki, H., Kitadai, Y., Ito, R., Nakayama, H., Yasui, W."Correlation of a single nucleotide polymorphism in the E-cadherin gene promoter with tumorigenesis and progression of gastric carcinoma in Japan". International Journal of Oncology 23.2 (2003): 421-427.
Chicago
Kuraoka, K., Oue, N., Yokozaki, H., Kitadai, Y., Ito, R., Nakayama, H., Yasui, W."Correlation of a single nucleotide polymorphism in the E-cadherin gene promoter with tumorigenesis and progression of gastric carcinoma in Japan". International Journal of Oncology 23, no. 2 (2003): 421-427. https://doi.org/10.3892/ijo.23.2.421