Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice

  • Authors:
    • Aishun Jin
    • Yunlong Qi
    • Etsuko Mori
    • Maowu Guo
    • Seiichi Takasaki
    • Tsuneatsu Mori
  • View Affiliations

  • Published online on: June 1, 2004     https://doi.org/10.3892/ijo.24.6.1523
  • Pages: 1523-1528
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Abstract

To further provide scientific evidence before clinical application, the anti-tumor effects of apoptosis inducing nucleosides (AINs) released from CD57+HLA-DRbright natural suppressor (CD57.DR-NS) cell line on human gastric carcinoma (GCIY)-bearing severe combined immunodeficiency (SCID) mice were examined by monitoring tumor cell growth and change of body weight of mice. The results obtained evidenced that AINs strongly induced apoptosis in the tumor tissues in SCID mice with decrease of tumor size and without loss of body weight. We found that peak 5 and peak 6 (P5 and P6) components among six components (AINs) isolated from CD57.DR-NS cell cultures by high performance liquid chromatograhy (HPLC) are the most effective. The anti-tumor effective dosage of P5, P6 and their mixture, P5+P6, were obtained in dose-dependent manner. Thus, the most effective method of administration of AINs for tumor regression without exhaustion was established in the present study. Corresponding to the previous study that AINs could generate apoptosis in malignant cells while lacking the toxicity in normal cells, the results obtained in the present preclinical experiments suggested anti-tumor efficacy of AINs with possible refrainment from side-effects in clinical trials.

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June 2004
Volume 24 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Jin A, Qi Y, Mori E, Guo M, Takasaki S and Mori T: Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice. Int J Oncol 24: 1523-1528, 2004
APA
Jin, A., Qi, Y., Mori, E., Guo, M., Takasaki, S., & Mori, T. (2004). Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice. International Journal of Oncology, 24, 1523-1528. https://doi.org/10.3892/ijo.24.6.1523
MLA
Jin, A., Qi, Y., Mori, E., Guo, M., Takasaki, S., Mori, T."Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice". International Journal of Oncology 24.6 (2004): 1523-1528.
Chicago
Jin, A., Qi, Y., Mori, E., Guo, M., Takasaki, S., Mori, T."Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice". International Journal of Oncology 24, no. 6 (2004): 1523-1528. https://doi.org/10.3892/ijo.24.6.1523