An investigation of the tylosis with oesophageal cancer (TOC) locus in Iranian patients with oesophageal squamous cell carcinoma

  • Authors:
    • M. Shahabi
    • M. R. Noori Daloii
    • J. E. Langan
    • L. Rowbottom
    • E. Jahanzad
    • E. Khoshbin
    • M. Taghikhani
    • J. K. Field
    • J. M. Risk
  • View Affiliations

  • Published online on: August 1, 2004     https://doi.org/10.3892/ijo.25.2.389
  • Pages: 389-395
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Abstract

Oesophageal cancer is one of the ten leading causes of cancer mortality worldwide. Earlier loss of heterozygosity (or allelic imbalance) studies have implicated regions on chromosomes 3p, 5q, 9p, 13q, 17p, 17q, and 18q in the development of sporadic oesophageal cancer and recent data have linked the familial tylosis with oesophageal cancer (TOC) gene-containing region on chromosome 17q25 with this cancer. We have studied allelic imbalance (AI) at microsatellite markers both closely linked to and distant from the TOC gene locus in 60 sporadic squamous cell oesophageal cancers from Iran and have investigated the most likely candidate gene by mutation analysis in these tumours. Forty-four out of these 60 samples (73%) show allelic imbalance at one or more loci within or adjacent to the TOC minimal region, while the highest incidence of AI was observed at the D17S2244 and D17S2246 loci (almost 70% AI in informative cases), correlating with the TOC minimal region. Analysis of the coding regions of a candidate gene in these tumours failed to show an equivalently high incidence of mutation, although two mutations and one polymorphism were observed. These data support and extend previous observations that the TOC region of chromosome 17q25 may be involved in the aetiology of the sporadic form of oesophageal cancer from a number of different geographical populations and suggest that the causative gene may be epigenetically silenced rather than mutated.

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August 2004
Volume 25 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Shahabi M, Noori Daloii MR, Langan JE, Rowbottom L, Jahanzad E, Khoshbin E, Taghikhani M, Field JK and Risk JM: An investigation of the tylosis with oesophageal cancer (TOC) locus in Iranian patients with oesophageal squamous cell carcinoma. Int J Oncol 25: 389-395, 2004
APA
Shahabi, M., Noori Daloii, M.R., Langan, J.E., Rowbottom, L., Jahanzad, E., Khoshbin, E. ... Risk, J.M. (2004). An investigation of the tylosis with oesophageal cancer (TOC) locus in Iranian patients with oesophageal squamous cell carcinoma. International Journal of Oncology, 25, 389-395. https://doi.org/10.3892/ijo.25.2.389
MLA
Shahabi, M., Noori Daloii, M. R., Langan, J. E., Rowbottom, L., Jahanzad, E., Khoshbin, E., Taghikhani, M., Field, J. K., Risk, J. M."An investigation of the tylosis with oesophageal cancer (TOC) locus in Iranian patients with oesophageal squamous cell carcinoma". International Journal of Oncology 25.2 (2004): 389-395.
Chicago
Shahabi, M., Noori Daloii, M. R., Langan, J. E., Rowbottom, L., Jahanzad, E., Khoshbin, E., Taghikhani, M., Field, J. K., Risk, J. M."An investigation of the tylosis with oesophageal cancer (TOC) locus in Iranian patients with oesophageal squamous cell carcinoma". International Journal of Oncology 25, no. 2 (2004): 389-395. https://doi.org/10.3892/ijo.25.2.389