Analyses of autoantibodies against tumor-associated antigens in patients with hepatocellular carcinoma

  • Authors:
    • Takashi Himoto
    • Shigeki Kuriyama
    • Jian-Ying Zhang
    • Edward K.L. Chan
    • Yasuhiko Kimura
    • Tsutomu Masaki
    • Naohito Uchida
    • Mikio Nishioka
    • Eng M. Tan
  • View Affiliations

  • Published online on: October 1, 2005     https://doi.org/10.3892/ijo.27.4.1079
  • Pages: 1079-1085
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Abstract

Autoantibodies against tumor-associated antigens (TAAs) such as insulin-like growth factor II mRNA-binding proteins (IMPs), p53, c-myc, and survivin were analyzed in patients with hepatocellular carcinoma (HCC), using recombinant proteins of these antigens. Eight of 86 (9.3%) HCC patients had one or more of these autoantibodies. However, serum α-fetoprotein (AFP) levels ranged within normal limits in HCC patients with anti-TAAs except for one case with anti-IMP1. One of the HCC patients had autoantibodies against IMP1, IMP3 and p53 before the diagnosis of HCC. These findings may indicate that anti-TAAs seem to be supplementary serological markers for the diagnosis of HCC in AFP-negative cases and that autoantibodies against IMP1, IMP3 and p53 are candidates for predictive markers of HCC development.

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October 2005
Volume 27 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Himoto T, Kuriyama S, Zhang J, Chan EK, Kimura Y, Masaki T, Uchida N, Nishioka M and Tan EM: Analyses of autoantibodies against tumor-associated antigens in patients with hepatocellular carcinoma. Int J Oncol 27: 1079-1085, 2005
APA
Himoto, T., Kuriyama, S., Zhang, J., Chan, E.K., Kimura, Y., Masaki, T. ... Tan, E.M. (2005). Analyses of autoantibodies against tumor-associated antigens in patients with hepatocellular carcinoma. International Journal of Oncology, 27, 1079-1085. https://doi.org/10.3892/ijo.27.4.1079
MLA
Himoto, T., Kuriyama, S., Zhang, J., Chan, E. K., Kimura, Y., Masaki, T., Uchida, N., Nishioka, M., Tan, E. M."Analyses of autoantibodies against tumor-associated antigens in patients with hepatocellular carcinoma". International Journal of Oncology 27.4 (2005): 1079-1085.
Chicago
Himoto, T., Kuriyama, S., Zhang, J., Chan, E. K., Kimura, Y., Masaki, T., Uchida, N., Nishioka, M., Tan, E. M."Analyses of autoantibodies against tumor-associated antigens in patients with hepatocellular carcinoma". International Journal of Oncology 27, no. 4 (2005): 1079-1085. https://doi.org/10.3892/ijo.27.4.1079