Suppression of SCC antigen promotes cancer cell invasion and migration through the decrease in E-cadherin expression

  • Authors:
    • Akihiro Murakami
    • Tatsushi Nakagawa
    • Mayumi Kaneko
    • Shugo Nawata
    • Osamu Takeda
    • Hiroshi Kato
    • Norihiro Sugino
  • View Affiliations

  • Published online on: November 1, 2006     https://doi.org/10.3892/ijo.29.5.1231
  • Pages: 1231-1235
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Abstract

Squamous cell carcinoma antigen (SCCA) is a useful tumor marker for diagnosis and management of squamous cell carcinoma. Recent studies have shown that SCCA can influence the behavior of cancer cells. It is well known that cell-cell adhesion is an important factor for the progression of cancer. The present study, therefore, was undertaken to investigate the effect of SCCA2 on the cell adhesion related molecule, E-cadherin, and cancer cell behavior. For this purpose, antisense SCCA2 cDNA was transfected into human uterine cancer cell lines, SKG IIIa and SiHa, which express SCCA2. Suppression of SCCA2 expression by antisense SCCA2 cDNA transfection decreased E-cadherin expression and promoted cell migration and invasion as well as the blockage of E-cadherin function by anti-E-cadherin antibody administration. In conclusion, SCCA2 regulates cell migration and invasion via E-cadherin expression, suggesting that SCCA2 may be involved in cancer behavior such as invasion or metastasis.

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November 2006
Volume 29 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Murakami A, Nakagawa T, Kaneko M, Nawata S, Takeda O, Kato H and Sugino N: Suppression of SCC antigen promotes cancer cell invasion and migration through the decrease in E-cadherin expression. Int J Oncol 29: 1231-1235, 2006
APA
Murakami, A., Nakagawa, T., Kaneko, M., Nawata, S., Takeda, O., Kato, H., & Sugino, N. (2006). Suppression of SCC antigen promotes cancer cell invasion and migration through the decrease in E-cadherin expression. International Journal of Oncology, 29, 1231-1235. https://doi.org/10.3892/ijo.29.5.1231
MLA
Murakami, A., Nakagawa, T., Kaneko, M., Nawata, S., Takeda, O., Kato, H., Sugino, N."Suppression of SCC antigen promotes cancer cell invasion and migration through the decrease in E-cadherin expression". International Journal of Oncology 29.5 (2006): 1231-1235.
Chicago
Murakami, A., Nakagawa, T., Kaneko, M., Nawata, S., Takeda, O., Kato, H., Sugino, N."Suppression of SCC antigen promotes cancer cell invasion and migration through the decrease in E-cadherin expression". International Journal of Oncology 29, no. 5 (2006): 1231-1235. https://doi.org/10.3892/ijo.29.5.1231