RASSF1A suppresses oncogenic H-Ras-induced c-Jun N-terminal kinase activation

  • Authors:
    • Young A. Yoo
    • Ah Ram Na
    • Myeong-Sok Lee
    • Sukjoon Yoon
    • Jun Suk Kim
  • View Affiliations

  • Published online on: December 1, 2006     https://doi.org/10.3892/ijo.29.6.1541
  • Pages: 1541-1547
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The constitutive activation of JNK has been implicated in Ras-induced cellular transformation and activated JNK is down-regulated by the tumor suppressor protein, RASSF1A. In this study, we examined whether RASSF1A blocked oncogenic Ras-induced JNK activation. Exogenous expression of H-RasG12V induced JNK phosphorylation and RASSF1A co-transfected with H-RasG12V efficiently suppressed Ras-triggered JNK activation in various cancer cell lines. RASSF1A expression revived the H-RasG12V-induced p27Kip1 down-regulation. JNK siRNA treatment also promoted recovery from the H-RasG12V-induced p27Kip1 down-regulation. These results demonstrate that RASSF1A inhibited H-RasG12V-induced JNK activation and JNK-mediated p27Kip1 down-regulation. From these results, we propose that RASSF1A exerts a tumor-suppressing effect by blocking oncogenic Ras-induced JNK activation.

Related Articles

Journal Cover

December 2006
Volume 29 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yoo YA, Na AR, Lee M, Yoon S and Kim JS: RASSF1A suppresses oncogenic H-Ras-induced c-Jun N-terminal kinase activation. Int J Oncol 29: 1541-1547, 2006
APA
Yoo, Y.A., Na, A.R., Lee, M., Yoon, S., & Kim, J.S. (2006). RASSF1A suppresses oncogenic H-Ras-induced c-Jun N-terminal kinase activation. International Journal of Oncology, 29, 1541-1547. https://doi.org/10.3892/ijo.29.6.1541
MLA
Yoo, Y. A., Na, A. R., Lee, M., Yoon, S., Kim, J. S."RASSF1A suppresses oncogenic H-Ras-induced c-Jun N-terminal kinase activation". International Journal of Oncology 29.6 (2006): 1541-1547.
Chicago
Yoo, Y. A., Na, A. R., Lee, M., Yoon, S., Kim, J. S."RASSF1A suppresses oncogenic H-Ras-induced c-Jun N-terminal kinase activation". International Journal of Oncology 29, no. 6 (2006): 1541-1547. https://doi.org/10.3892/ijo.29.6.1541