ACCUMULATION OF MUTANT P53 PROTEIN CORRELATES WITH ELEVATION OF SERUM AFP IN HUMAN HEPATOCELLULAR-CARCINOMA

  • Authors:
    • Y CHEN
    • ZY TANG
    • KD LIU
    • SL YE
    • XD ZHOU
    • YQ YU
    • HQ ZHOU
    • WH BAO
  • View Affiliations

  • Published online on: August 1, 1993     https://doi.org/10.3892/ijo.3.2.157
  • Pages: 157-160
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Abstract

A total of 88 specimens of hepatocellular carcinoma (HCC) and its surrounding liver tissues were studied to assess the role of a mutant p53 protein in HCC. The mutant p53 protein was evaluated by an immunoperoxidase detection system. Mutant p53 protein was detected in 46.6% of HCC specimens, and in 70.6% of surrounding liver tissues. A statistically significant association was found between the elevation of serum AFP and the accumulation of mutant p53 in HCCs (P<0.05), and in surrounding liver tissues (P<0.005). These results imply that mutant p53 protein may function as a regulatory factor in the transcription of the AFP gene during development of HCC.

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August 1993
Volume 3 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
CHEN Y, TANG Z, LIU K, YE S, ZHOU X, YU Y, ZHOU H and BAO W: ACCUMULATION OF MUTANT P53 PROTEIN CORRELATES WITH ELEVATION OF SERUM AFP IN HUMAN HEPATOCELLULAR-CARCINOMA. Int J Oncol 3: 157-160, 1993
APA
CHEN, Y., TANG, Z., LIU, K., YE, S., ZHOU, X., YU, Y. ... BAO, W. (1993). ACCUMULATION OF MUTANT P53 PROTEIN CORRELATES WITH ELEVATION OF SERUM AFP IN HUMAN HEPATOCELLULAR-CARCINOMA. International Journal of Oncology, 3, 157-160. https://doi.org/10.3892/ijo.3.2.157
MLA
CHEN, Y., TANG, Z., LIU, K., YE, S., ZHOU, X., YU, Y., ZHOU, H., BAO, W."ACCUMULATION OF MUTANT P53 PROTEIN CORRELATES WITH ELEVATION OF SERUM AFP IN HUMAN HEPATOCELLULAR-CARCINOMA". International Journal of Oncology 3.2 (1993): 157-160.
Chicago
CHEN, Y., TANG, Z., LIU, K., YE, S., ZHOU, X., YU, Y., ZHOU, H., BAO, W."ACCUMULATION OF MUTANT P53 PROTEIN CORRELATES WITH ELEVATION OF SERUM AFP IN HUMAN HEPATOCELLULAR-CARCINOMA". International Journal of Oncology 3, no. 2 (1993): 157-160. https://doi.org/10.3892/ijo.3.2.157