CHROMOSOMAL MARKERS AS PROGNOSTIC INDICATORS IN TRANSITIONAL-CELL CARCINOMAS OF THE BLADDER

  • Authors:
    • Z DOBROWOLSKI
    • B PAPLA
  • View Affiliations

  • Published online on: August 1, 1993     https://doi.org/10.3892/ijo.3.2.219
  • Pages: 219-221
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Abstract

Clinical-cytogenetic correlations were assessed in 79 patients with transitional cell carcinomas of the bladder to whom cytogenetic analysis of the primary tumor had been successful. High-grade (G2+G3) and high-stage (T2-T4) tumors had in general a higher ploidy level and contained more marker chromosomes, including multiple markers, compared to low-grade (G0+G1) and low stage (Ta+T1) tumors. The early recurrence rate (within 7 months) was significantly higher (p<0.05) in patients whose tumors contained marker chromosomes compared to cases without markers. Also, a significantly higher proportion of patients with marker chromosomes died due to their disease during the study period (follow-up time 30 months) compared to those without markers (84% versus 16%, p<0.005). The results confirm and extend previous studies showing that cytogenetic findings may be an important prognostic indicator in bladder cancer patients.

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August 1993
Volume 3 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
DOBROWOLSKI Z and DOBROWOLSKI Z: CHROMOSOMAL MARKERS AS PROGNOSTIC INDICATORS IN TRANSITIONAL-CELL CARCINOMAS OF THE BLADDER. Int J Oncol 3: 219-221, 1993
APA
DOBROWOLSKI, Z., & DOBROWOLSKI, Z. (1993). CHROMOSOMAL MARKERS AS PROGNOSTIC INDICATORS IN TRANSITIONAL-CELL CARCINOMAS OF THE BLADDER. International Journal of Oncology, 3, 219-221. https://doi.org/10.3892/ijo.3.2.219
MLA
DOBROWOLSKI, Z., PAPLA, B."CHROMOSOMAL MARKERS AS PROGNOSTIC INDICATORS IN TRANSITIONAL-CELL CARCINOMAS OF THE BLADDER". International Journal of Oncology 3.2 (1993): 219-221.
Chicago
DOBROWOLSKI, Z., PAPLA, B."CHROMOSOMAL MARKERS AS PROGNOSTIC INDICATORS IN TRANSITIONAL-CELL CARCINOMAS OF THE BLADDER". International Journal of Oncology 3, no. 2 (1993): 219-221. https://doi.org/10.3892/ijo.3.2.219