PROGNOSTIC VALUE OF SERUM PEPSINOGEN LEVELS IN PATIENTS WITH GASTRIC-CARCINOMA

  • Authors:
    • K MAEDA
    • YS CHUNG
    • N ONODA
    • S NISIMURA
    • A NITTA
    • Y ARIMOTO
    • Y KATO
    • M SOWA
  • View Affiliations

  • Published online on: September 1, 1993     https://doi.org/10.3892/ijo.3.3.437
  • Pages: 437-440
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Abstract

Serum pepsinogen levels were examined in 107 patients with gastric carcinoma, by immunoradiometric assay for evaluating its clinical usefulness in gastric cancer. The mean serum pepsinogen-I (PG-I) level and the pepsinogen-I/pepsinogen-II (PG-I/II) ratio decreased as the histologic stage increased. Also, serum pepsinogen-II (PG-II) correspondingly increased with the increase of histologic stage. Moreover, in patients with low PG-I/II (<2.0), prognosis was significantly poorer than in those with high PG-I/II (greater-than-or-equal-to 2.0). The rate of recurrence after a curative resection was significantly higher in patients with low PG-I/II. These results suggest that measurement of serum pepsinogens and calculation of PG-I/II are useful for prediction of the tumor stage, and PG-I/II may be a prognostic indicator for gastric carcinoma.

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September 1993
Volume 3 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
MAEDA K, CHUNG Y, ONODA N, NISIMURA S, NITTA A, ARIMOTO Y, KATO Y and SOWA M: PROGNOSTIC VALUE OF SERUM PEPSINOGEN LEVELS IN PATIENTS WITH GASTRIC-CARCINOMA. Int J Oncol 3: 437-440, 1993
APA
MAEDA, K., CHUNG, Y., ONODA, N., NISIMURA, S., NITTA, A., ARIMOTO, Y. ... SOWA, M. (1993). PROGNOSTIC VALUE OF SERUM PEPSINOGEN LEVELS IN PATIENTS WITH GASTRIC-CARCINOMA. International Journal of Oncology, 3, 437-440. https://doi.org/10.3892/ijo.3.3.437
MLA
MAEDA, K., CHUNG, Y., ONODA, N., NISIMURA, S., NITTA, A., ARIMOTO, Y., KATO, Y., SOWA, M."PROGNOSTIC VALUE OF SERUM PEPSINOGEN LEVELS IN PATIENTS WITH GASTRIC-CARCINOMA". International Journal of Oncology 3.3 (1993): 437-440.
Chicago
MAEDA, K., CHUNG, Y., ONODA, N., NISIMURA, S., NITTA, A., ARIMOTO, Y., KATO, Y., SOWA, M."PROGNOSTIC VALUE OF SERUM PEPSINOGEN LEVELS IN PATIENTS WITH GASTRIC-CARCINOMA". International Journal of Oncology 3, no. 3 (1993): 437-440. https://doi.org/10.3892/ijo.3.3.437