SUCCESSFUL THERAPY TO A PROGRESSIVE TUMOR USING MONOCLONAL-ANTIBODIES TO T-CELL REGULATORY MOLECULES AND INTERLEUKIN-2

  • Authors:
    • B HORVAT
    • AF RODRIGUEZ
    • E BREWER
    • PM FLOOD
  • View Affiliations

  • Published online on: September 1, 1993     https://doi.org/10.3892/ijo.3.3.503
  • Pages: 503-511
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Abstract

Weekly injections of monoclonal antibodies (mAb) to T-cell regulatory molecules, into animals challenged with a progressively growing epithelial cell tumor 3152-PRO, decreased tumor incidence and caused significantly slower tumor growth, compared with animals given identical treatments of control rat mAb. Some of the mAb showed significant synergy with rIL-2 in the successful therapeutic treatment of 3152-PRO. Furthermore, spleen cells from treated mice generated strong tumor-specific cytotoxic activity. The successful elimination of progressively growing 3152-PRO tumor rendered animals specifically resistant to a secondary challenge of 3152-PRO tumor cells, but not to 2237-PRO or 3256-PRO, two other, noncrossreactive tumors.

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September 1993
Volume 3 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
HORVAT B, RODRIGUEZ A, BREWER E and FLOOD P: SUCCESSFUL THERAPY TO A PROGRESSIVE TUMOR USING MONOCLONAL-ANTIBODIES TO T-CELL REGULATORY MOLECULES AND INTERLEUKIN-2. Int J Oncol 3: 503-511, 1993
APA
HORVAT, B., RODRIGUEZ, A., BREWER, E., & FLOOD, P. (1993). SUCCESSFUL THERAPY TO A PROGRESSIVE TUMOR USING MONOCLONAL-ANTIBODIES TO T-CELL REGULATORY MOLECULES AND INTERLEUKIN-2. International Journal of Oncology, 3, 503-511. https://doi.org/10.3892/ijo.3.3.503
MLA
HORVAT, B., RODRIGUEZ, A., BREWER, E., FLOOD, P."SUCCESSFUL THERAPY TO A PROGRESSIVE TUMOR USING MONOCLONAL-ANTIBODIES TO T-CELL REGULATORY MOLECULES AND INTERLEUKIN-2". International Journal of Oncology 3.3 (1993): 503-511.
Chicago
HORVAT, B., RODRIGUEZ, A., BREWER, E., FLOOD, P."SUCCESSFUL THERAPY TO A PROGRESSIVE TUMOR USING MONOCLONAL-ANTIBODIES TO T-CELL REGULATORY MOLECULES AND INTERLEUKIN-2". International Journal of Oncology 3, no. 3 (1993): 503-511. https://doi.org/10.3892/ijo.3.3.503