EVALUATION OF THE ANTINEOPLASTIC ACTIVITIES OF THE RIMINOPHENAZINE AGENTS CLOFAZIMINE AND B669 IN TUMOR-BEARING RATS AND MICE
- Authors:
- Published online on: November 1, 1993 https://doi.org/10.3892/ijo.3.5.1011
- Pages: 1011-1013
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Abstract
The riminophenazine agents clofazimine and its analogue B669 displayed anti-tumor activity at 30 mg/kg/day in benzo[a]pyrene (BP) induced sarcomas of mice as well as dimethylbenz-anthracene (DMBA)-induced rat mammary tumors. No hematological toxicity of these drugs at doses up to 60 mg/kg/day for one month was observed. This is the first study to document in vivo anti-neoplastic activities of clofazimine and B669.