Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4

  • Authors:
    • Lara Tickenbrock
    • Sina Hehn
    • Bülent Sargin
    • Chunaram Choudhary
    • Nicole Bäumer
    • Horst Buerger
    • Bernd Schulte
    • Oliver Müller
    • Wolfgang E. Berdel
    • Carsten Müller-Tidow
    • Hubert Serve
  • View Affiliations

  • Published online on: December 1, 2008     https://doi.org/10.3892/ijo_00000111
  • Pages: 1215-1221
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Abstract

Wnt signalling regulates proliferation, self renewal and cell fate. Aberrant Wnt signalling is thought to contribute to AML pathogenesis by enhancing self renewal. Herein, we provide evidence for increased expression of Frizzled-4, a receptor for Wnt ligands, in primary AML blasts compared to normal bone marrow on the protein level. In addition, Frizzled-4 is highly expressed in human CD34 positive cells as well as in lineage negative sorted mouse bone marrow cells. Functionally, Frizzled-4 expression modulates apoptosis and enhances Wnt3a induced β-catenin stability in myeloid progenitor cells. Frizzled-4-dependent β-catenin stabilization is dkk-1 sensitive, implicating a specific Wnt-ligand/Frizzled-receptor interaction. These findings indicate enhanced sensitivity of AML blasts for Wnt-ligands and suggest an additional mechanism of Wnt signalling activation in the pathogenesis of AML.

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December 2008
Volume 33 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Tickenbrock L, Hehn S, Sargin B, Choudhary C, Bäumer N, Buerger H, Schulte B, Müller O, Berdel WE, Müller-Tidow C, Müller-Tidow C, et al: Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4. Int J Oncol 33: 1215-1221, 2008
APA
Tickenbrock, L., Hehn, S., Sargin, B., Choudhary, C., Bäumer, N., Buerger, H. ... Serve, H. (2008). Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4. International Journal of Oncology, 33, 1215-1221. https://doi.org/10.3892/ijo_00000111
MLA
Tickenbrock, L., Hehn, S., Sargin, B., Choudhary, C., Bäumer, N., Buerger, H., Schulte, B., Müller, O., Berdel, W. E., Müller-Tidow, C., Serve, H."Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4". International Journal of Oncology 33.6 (2008): 1215-1221.
Chicago
Tickenbrock, L., Hehn, S., Sargin, B., Choudhary, C., Bäumer, N., Buerger, H., Schulte, B., Müller, O., Berdel, W. E., Müller-Tidow, C., Serve, H."Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4". International Journal of Oncology 33, no. 6 (2008): 1215-1221. https://doi.org/10.3892/ijo_00000111