Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK

  • Authors:
    • Dong Yeok Shin
    • Won Sup Lee
    • Jing Nan Lu
    • Myung Hee Kang
    • Chung Ho Ryu
    • Gi Young Kim
    • Ho Sung Kang
    • Sung Chul Shin
    • Yung Hyun Choi
  • View Affiliations

  • Published online on: December 1, 2009     https://doi.org/10.3892/ijo_00000469
  • Pages: 1499-1504
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Abstract

Anthocyanins belong to a class of flavonoids that exhibit important anti-oxidant and anti-inflammatory actions as well as chemotherapeutic effects. However, little is known concerning the molecular mechanisms by which these activities are exerted. In this study, we investigated the anthocyanins isolated from Vitis coignetiae Pulliat for their potential anti-proliferative and apoptotic effects on human colon cancer HCT-116 cells. These anthocyanins inhibited cell viability and induce apoptotic cell death of HCT-116 cells in a dose-dependent manner. The apoptotic cell death was caspase-dependent and the anthocyanins regulated anti-apoptotic proteins (IAPs). In addition, apoptosis was associated with activation of p38-MAPK and suppression of Akt. In conclusion, this study suggests that the anthocyanins isolated from Vitis coignetiae Pulliat induce apoptosis might at least in part through activating p38-MAPK and suppressing Akt in human colon cancer HCT-116 cells.

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December 2009
Volume 35 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Shin DY, Lee WS, Lu JN, Kang MH, Ryu CH, Kim GY, Kang HS, Shin SC and Choi YH: Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK. Int J Oncol 35: 1499-1504, 2009
APA
Shin, D.Y., Lee, W.S., Lu, J.N., Kang, M.H., Ryu, C.H., Kim, G.Y. ... Choi, Y.H. (2009). Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK. International Journal of Oncology, 35, 1499-1504. https://doi.org/10.3892/ijo_00000469
MLA
Shin, D. Y., Lee, W. S., Lu, J. N., Kang, M. H., Ryu, C. H., Kim, G. Y., Kang, H. S., Shin, S. C., Choi, Y. H."Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK". International Journal of Oncology 35.6 (2009): 1499-1504.
Chicago
Shin, D. Y., Lee, W. S., Lu, J. N., Kang, M. H., Ryu, C. H., Kim, G. Y., Kang, H. S., Shin, S. C., Choi, Y. H."Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK". International Journal of Oncology 35, no. 6 (2009): 1499-1504. https://doi.org/10.3892/ijo_00000469