Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation

  • Authors:
    • Hideo Nakajima
    • Yasuhito Ishigaki
    • Qi-Sheng Xia
    • Takayuki Ikeda
    • Yoshino Yoshitake
    • Hideto Yonekura
    • Takayuki Nojima
    • Takuji Tanaka
    • Hisanori Umehara
    • Naohisa Tomosugi
    • Takanobu Takata
    • Takeo Shimasaki
    • Naoki Nakaya
    • Itaru Sato
    • Kazuyuki Kawakami
    • Keita Koizumi
    • Toshinari Minamoto
    • Yoshiharu Motoo
  • View Affiliations

  • Published online on: September 1, 2010     https://doi.org/10.3892/ijo_00000707
  • Pages: 583-593
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Abstract

The Family with sequence similarity 107 (FAM107) possesses an N-terminal domain of unknown function (DUF1151) that is highly conserved beyond species. In human, FAM107A termed TU3A/DRR1 has been reported as a candidate tumor suppressor gene which expression is downregulated in several types of cancer, however no studies have investigated the other family protein, FAM107B. In the present study, we designated FAM107B as heat shock-inducible tumor small protein (HITS) and studied its expression and functional properties in cancer. HITS is an 18-kDa nuclear protein expressed in a variety of tissues including stomach, colon, lung and lymphoid organs. In human gastric and colorectal cancers and a mouse model of colon cancer, its expression in tumor cells was much lower than normal epithelial cells, while expression pattern and intensity varied among different histological types of cancer. In functional analysis in vitro, forced expression of this protein suppresses the cellular responses to growth factors. Furthermore, HITS gene carries the promoter region providing heat shock transcription factor (HSF) binding sites and amplifying the transcription of HITS by heat shock or hyperthermia treatment both in vitro and in vivo. Thus HITS would be a potential tumor suppressor gene similar to TU3A containing heat responding elements, which contrasts with previously described oncogenic activities of other heat shock proteins such as HSP70 and HSP90.

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September 2010
Volume 37 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Nakajima H, Ishigaki Y, Xia Q, Ikeda T, Yoshitake Y, Yonekura H, Nojima T, Tanaka T, Umehara H, Tomosugi N, Tomosugi N, et al: Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation. Int J Oncol 37: 583-593, 2010
APA
Nakajima, H., Ishigaki, Y., Xia, Q., Ikeda, T., Yoshitake, Y., Yonekura, H. ... Motoo, Y. (2010). Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation. International Journal of Oncology, 37, 583-593. https://doi.org/10.3892/ijo_00000707
MLA
Nakajima, H., Ishigaki, Y., Xia, Q., Ikeda, T., Yoshitake, Y., Yonekura, H., Nojima, T., Tanaka, T., Umehara, H., Tomosugi, N., Takata, T., Shimasaki, T., Nakaya, N., Sato, I., Kawakami, K., Koizumi, K., Minamoto, T., Motoo, Y."Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation". International Journal of Oncology 37.3 (2010): 583-593.
Chicago
Nakajima, H., Ishigaki, Y., Xia, Q., Ikeda, T., Yoshitake, Y., Yonekura, H., Nojima, T., Tanaka, T., Umehara, H., Tomosugi, N., Takata, T., Shimasaki, T., Nakaya, N., Sato, I., Kawakami, K., Koizumi, K., Minamoto, T., Motoo, Y."Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation". International Journal of Oncology 37, no. 3 (2010): 583-593. https://doi.org/10.3892/ijo_00000707