TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma

  • Authors:
    • Hairong Luo
    • Xiangfang Hao
    • Chao Ge
    • Fangyu Zhao
    • Miaoxin Zhu
    • Taoyang Chen
    • Ming Yao
    • Xianghuo He
    • Jinjun Li
  • View Affiliations

  • Published online on: October 1, 2010     https://doi.org/10.3892/ijo_00000736
  • Pages: 853-859
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Abstract

Hepatocellular carcinoma (HCC) is an aggressive type of cancer, and it may be at an advanced stage when it is detected. It has been shown that TC21, a member of the Ras superfamily, is associated with the proliferation, migration and transformation of tumor cells. Previous studies have shown that TC21 is overexpressed in breast, esophageal and oral carcinomas, and that it is closely associated with the early stages of tumorigenesis. In this study, we demonstrate that TC21 overexpression promotes the motility of HCC cells in vitro and intrahepatic metastasis in vivo. Furthermore, experiments examining the effects of both the ectopic expression of TC21 and siRNA treatment in HCC cells showed that TC21 alters the expression of the adhesive molecules E-cadherin and N-cadherin. Our data suggest that TC21 is associated with tumor progression and poor prognosis in HCC.

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October 2010
Volume 37 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Luo H, Hao X, Ge C, Zhao F, Zhu M, Chen T, Yao M, He X and Li J: TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma. Int J Oncol 37: 853-859, 2010
APA
Luo, H., Hao, X., Ge, C., Zhao, F., Zhu, M., Chen, T. ... Li, J. (2010). TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma. International Journal of Oncology, 37, 853-859. https://doi.org/10.3892/ijo_00000736
MLA
Luo, H., Hao, X., Ge, C., Zhao, F., Zhu, M., Chen, T., Yao, M., He, X., Li, J."TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma". International Journal of Oncology 37.4 (2010): 853-859.
Chicago
Luo, H., Hao, X., Ge, C., Zhao, F., Zhu, M., Chen, T., Yao, M., He, X., Li, J."TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma". International Journal of Oncology 37, no. 4 (2010): 853-859. https://doi.org/10.3892/ijo_00000736