Expression of α-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor

  • Authors:
    • Natsuko Ohtomo
    • Tomoaki Tomiya
    • Yasushi Tanoue
    • Yukiko Inoue
    • Takako Nishikawa
    • Hitoshi Ikeda
    • Yasuji Seyama
    • Norihiro Kokudo
    • Junji Shibahara
    • Masashi Fukayama
    • Kazuhiko Koike
    • Hiromichi Shirataki
    • Kenji Fujiwara
  • View Affiliations

  • Published online on: December 1, 2010     https://doi.org/10.3892/ijo_00000793
  • Pages: 1417-1423
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Abstract

The membrane traffic system has been recognized to be involved in carcinogenesis and tumor progression in several types of tumors. α-taxilin is a newly identified membrane traffic-related molecule, and its up-regulation has been reported in embryonic and malignant tissues of neural origin. In the present study, we analyzed the expression of α-taxilin in relation to clinicopathological features of hepatocellular carcinomas (HCC) and proliferative activity of the tumor determined by proliferating cell nuclear antigen labeling index (PCNA-LI). Twenty-nine surgically resected nodules of HCC (8 well-, 11 moderately-, and 10 poorly-differentiated) were studied. Fifteen cases showed ‘strong staining’, while 14 cases showed ‘weak staining’ for α-taxilin. A significantly higher expression of α-taxilin was observed in less-differentiated (p=0.005), and more invasive (p=0.016) HCCs. The ‘strong staining’ group showed significantly higher PCNA-LI than the ‘weak staining’ group (the medians of PCNA-LI were 59.4% vs. 14.4%, p<0.0001). We also evaluated the expression of α-taxilin in hepatoma cell lines (PLC/PRF/5, Hep G2 and HuH-6) in association with cell proliferation. The expression levels of α-taxilin protein were correlated with their growth rates. In conclusion, the expression of the α-taxilin protein was related with an increased proliferative activity and a less-differentiated histological grade of HCC. α-taxilin may be involved in cell proliferation of HCC, and its expression can be a marker of malignant potential of HCC.

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December 2010
Volume 37 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Ohtomo N, Tomiya T, Tanoue Y, Inoue Y, Nishikawa T, Ikeda H, Seyama Y, Kokudo N, Shibahara J, Fukayama M, Fukayama M, et al: Expression of α-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor. Int J Oncol 37: 1417-1423, 2010
APA
Ohtomo, N., Tomiya, T., Tanoue, Y., Inoue, Y., Nishikawa, T., Ikeda, H. ... Fujiwara, K. (2010). Expression of α-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor. International Journal of Oncology, 37, 1417-1423. https://doi.org/10.3892/ijo_00000793
MLA
Ohtomo, N., Tomiya, T., Tanoue, Y., Inoue, Y., Nishikawa, T., Ikeda, H., Seyama, Y., Kokudo, N., Shibahara, J., Fukayama, M., Koike, K., Shirataki, H., Fujiwara, K."Expression of α-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor". International Journal of Oncology 37.6 (2010): 1417-1423.
Chicago
Ohtomo, N., Tomiya, T., Tanoue, Y., Inoue, Y., Nishikawa, T., Ikeda, H., Seyama, Y., Kokudo, N., Shibahara, J., Fukayama, M., Koike, K., Shirataki, H., Fujiwara, K."Expression of α-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor". International Journal of Oncology 37, no. 6 (2010): 1417-1423. https://doi.org/10.3892/ijo_00000793