P75 neurotrophin receptor is sequestered in the Golgi apparatus of the U-87 MG human glioblastoma cell line

  • Authors:
    • Stéphanie Giraud
    • Elodie Loum
    • Barbara Bessette
    • Muriel Mathonnet
    • Fabrice Lalloué
  • View Affiliations

  • Published online on: December 6, 2010     https://doi.org/10.3892/ijo.2010.862
  • Pages: 391-399
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The P75 neurotrophin receptor (p75NTR) is a cell surface receptor that can induce apoptosis in many cell types. This receptor plays a major role in the development of the central nervous system and is expressed in some adult brain cells. Its implication in cell apoptosis or survival is probably of major importance in cellular homeostasis and thus p75NTR could be implicated in tumor resistance to death. In this study, we investigated the intracellular expression of p75NTR in a human glioblastoma cell line. Detection of p75NTR receptor in Golgi apparatus by immunofluorescence microscopy, or after Golgi apparatus extraction, could be correlated with a decrease of cell apoptosis leading cells to become tumorous. This hypothesis is supported by a loss of ligand-induced apoptosis in this cell line. Our observations show that p75NTR can be sequestered in the Golgi complex and could then be, in part, responsible for the cell resistance to apoptosis and for brain tumor formation.

Related Articles

Journal Cover

February 2011
Volume 38 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Giraud S, Loum E, Bessette B, Mathonnet M and Lalloué F: P75 neurotrophin receptor is sequestered in the Golgi apparatus of the U-87 MG human glioblastoma cell line. Int J Oncol 38: 391-399, 2011
APA
Giraud, S., Loum, E., Bessette, B., Mathonnet, M., & Lalloué, F. (2011). P75 neurotrophin receptor is sequestered in the Golgi apparatus of the U-87 MG human glioblastoma cell line. International Journal of Oncology, 38, 391-399. https://doi.org/10.3892/ijo.2010.862
MLA
Giraud, S., Loum, E., Bessette, B., Mathonnet, M., Lalloué, F."P75 neurotrophin receptor is sequestered in the Golgi apparatus of the U-87 MG human glioblastoma cell line". International Journal of Oncology 38.2 (2011): 391-399.
Chicago
Giraud, S., Loum, E., Bessette, B., Mathonnet, M., Lalloué, F."P75 neurotrophin receptor is sequestered in the Golgi apparatus of the U-87 MG human glioblastoma cell line". International Journal of Oncology 38, no. 2 (2011): 391-399. https://doi.org/10.3892/ijo.2010.862