BCL-2 GENE PREVENTS APOPTOSIS IN MURINE ACTH-SECRETING ADENOMA CELLS INDUCED BY BROMOCRIPTINE

  • Authors:
    • D YIN
    • S KONDO
    • J TAKEUCHI
    • T MORIMURA
    • DL VAUX
  • View Affiliations

  • Published online on: January 1, 1994     https://doi.org/10.3892/ijo.4.1.187
  • Pages: 187-191
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Bromocriptine, a dopamine agonist, is now an accepted primary therapeutic agent for patients with prolactinomas and other pituitary adenomas. However, the mechanism by which bromocriptine decreases elevated serum levels of prolactin or growth hormone and shrinks tumors by diminishing tumor cell size is not clear. Recently, we obtained bromocriptine induced apoptosis in murine ACTH-secreting pituitary adenoma (AtT-20) cells, based on DNA fragmentation assay and cell cycle analysis (unpublished data). In this study, we demonstrate that enforced expression of bcl-2 gene in AtT-20 cells by the MPZenNeo(bcl-2) retroviral gene transfer increased resistance to apoptosis induced by bromocriptine.

Related Articles

Journal Cover

January 1994
Volume 4 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
YIN D, KONDO S, TAKEUCHI J, MORIMURA T and VAUX D: BCL-2 GENE PREVENTS APOPTOSIS IN MURINE ACTH-SECRETING ADENOMA CELLS INDUCED BY BROMOCRIPTINE. Int J Oncol 4: 187-191, 1994
APA
YIN, D., KONDO, S., TAKEUCHI, J., MORIMURA, T., & VAUX, D. (1994). BCL-2 GENE PREVENTS APOPTOSIS IN MURINE ACTH-SECRETING ADENOMA CELLS INDUCED BY BROMOCRIPTINE. International Journal of Oncology, 4, 187-191. https://doi.org/10.3892/ijo.4.1.187
MLA
YIN, D., KONDO, S., TAKEUCHI, J., MORIMURA, T., VAUX, D."BCL-2 GENE PREVENTS APOPTOSIS IN MURINE ACTH-SECRETING ADENOMA CELLS INDUCED BY BROMOCRIPTINE". International Journal of Oncology 4.1 (1994): 187-191.
Chicago
YIN, D., KONDO, S., TAKEUCHI, J., MORIMURA, T., VAUX, D."BCL-2 GENE PREVENTS APOPTOSIS IN MURINE ACTH-SECRETING ADENOMA CELLS INDUCED BY BROMOCRIPTINE". International Journal of Oncology 4, no. 1 (1994): 187-191. https://doi.org/10.3892/ijo.4.1.187