THE ROLE OF NATURAL-KILLER-CELLS IN THE PATHOGENESIS OF EPSTEIN-BARR VIRUS-ASSOCIATED BURKITT-LYMPHOMA IN A SCID MOUSE MODEL

  • Authors:
    • BZ KATZ
    • B SALIMI
    • U SAINI
    • JG MCNAMARA
    • RN EISEN
  • View Affiliations

  • Published online on: January 1, 1994     https://doi.org/10.3892/ijo.4.1.225
  • Pages: 225-229
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Abstract

Epstein-Barr virus (EBV) is associated with both benign and malignant lymphoproliferative processes. Recently, mice with severe combined immunodeficiency (SCID) have been described that develop EBV-induced lymphomas when inoculated with peripheral blood lymphocytes from EBV-seropositive individuals. To investigate the pathogenesis of EBV-associated Burkitt lymphomas, we intraperitoneally inoculated SCID mice with cells from EBV-infected Burkitt lymphoma (BL) cell lines. In general, cells from BL lines developed into BL-like tumors. Certain BL cell lines, however, were not particularly tumorigenic in these animals. Antibody capable of depleting mice of natural killer cells (anti-asialo GM1) favored the development of these Burkitt lymphomas. The pathogenetic implications of this animal model for human disease is discussed.

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January 1994
Volume 4 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
KATZ B, SALIMI B, SAINI U, MCNAMARA J and EISEN R: THE ROLE OF NATURAL-KILLER-CELLS IN THE PATHOGENESIS OF EPSTEIN-BARR VIRUS-ASSOCIATED BURKITT-LYMPHOMA IN A SCID MOUSE MODEL. Int J Oncol 4: 225-229, 1994
APA
KATZ, B., SALIMI, B., SAINI, U., MCNAMARA, J., & EISEN, R. (1994). THE ROLE OF NATURAL-KILLER-CELLS IN THE PATHOGENESIS OF EPSTEIN-BARR VIRUS-ASSOCIATED BURKITT-LYMPHOMA IN A SCID MOUSE MODEL. International Journal of Oncology, 4, 225-229. https://doi.org/10.3892/ijo.4.1.225
MLA
KATZ, B., SALIMI, B., SAINI, U., MCNAMARA, J., EISEN, R."THE ROLE OF NATURAL-KILLER-CELLS IN THE PATHOGENESIS OF EPSTEIN-BARR VIRUS-ASSOCIATED BURKITT-LYMPHOMA IN A SCID MOUSE MODEL". International Journal of Oncology 4.1 (1994): 225-229.
Chicago
KATZ, B., SALIMI, B., SAINI, U., MCNAMARA, J., EISEN, R."THE ROLE OF NATURAL-KILLER-CELLS IN THE PATHOGENESIS OF EPSTEIN-BARR VIRUS-ASSOCIATED BURKITT-LYMPHOMA IN A SCID MOUSE MODEL". International Journal of Oncology 4, no. 1 (1994): 225-229. https://doi.org/10.3892/ijo.4.1.225