EXPRESSION OF ETS FAMILY GENES IN HEMATOPOIETIC-CELLS

  • Authors:
    • V ROMANO-SPICA
    • H SUZUKI
    • P GEORGIOU
    • SL CHEN
    • R ASCIONE
    • TS PAPAS
    • NK BHAT
  • View Affiliations

  • Published online on: March 1, 1994     https://doi.org/10.3892/ijo.4.3.521
  • Pages: 521-531
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Abstract

We have examined the expression of the ets family of transcription factors in different types of hematopoietic cells. Our results demonstrate that several members of the ets gene family are expressed differentially in hematopoietic cells. During phorbol ester induced differentiation of HL60 cells, ETS2, PEA3, as well as GABPalpha and GABPbeta mRNAs are coordinately induced. During the activation of T-cells, ETS2 proteins are induced; however, the expression of the ETS1 and ERGB gene products are reduced. These results demonstrate that the regulation of ets family of genes is complex and depends on cell type. This observation leads to the conclusion that the regulation of ets target genes, will be dependent, in part, upon the type of ets genes expressed in each particular cell type.

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March 1994
Volume 4 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
ROMANO-SPICA V, SUZUKI H, GEORGIOU P, CHEN S, ASCIONE R, PAPAS T and BHAT N: EXPRESSION OF ETS FAMILY GENES IN HEMATOPOIETIC-CELLS. Int J Oncol 4: 521-531, 1994
APA
ROMANO-SPICA, V., SUZUKI, H., GEORGIOU, P., CHEN, S., ASCIONE, R., PAPAS, T., & BHAT, N. (1994). EXPRESSION OF ETS FAMILY GENES IN HEMATOPOIETIC-CELLS. International Journal of Oncology, 4, 521-531. https://doi.org/10.3892/ijo.4.3.521
MLA
ROMANO-SPICA, V., SUZUKI, H., GEORGIOU, P., CHEN, S., ASCIONE, R., PAPAS, T., BHAT, N."EXPRESSION OF ETS FAMILY GENES IN HEMATOPOIETIC-CELLS". International Journal of Oncology 4.3 (1994): 521-531.
Chicago
ROMANO-SPICA, V., SUZUKI, H., GEORGIOU, P., CHEN, S., ASCIONE, R., PAPAS, T., BHAT, N."EXPRESSION OF ETS FAMILY GENES IN HEMATOPOIETIC-CELLS". International Journal of Oncology 4, no. 3 (1994): 521-531. https://doi.org/10.3892/ijo.4.3.521