HER2 NEU OVEREXPRESSION COUNTERACTS THE GROWTH EFFECTS OF C-MYC IN BREAST-CANCER CELLS

  • Authors:
    • SJ MILLER
    • MC HUNG
  • View Affiliations

  • Published online on: April 1, 1994     https://doi.org/10.3892/ijo.4.4.965
  • Pages: 965-969
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Abstract

Amplification and overexpression of the c-myc gene and/or the HER2/neu gene are common events in many human breast cancers. Studying the effects of increasing c-myc expression in breast cancer cell lines, we found that the anchorage-dependent growth rate of cells overexpressing HER2/neu is not affected by increased c-myc expression, whereas enhanced expression of c-myc in cells that do not overexpress HER2/neu can slow that growth rate. Increased c-myc expression did not affect anchorage-independent growth in soft agarose in any of the cells, and it slowed the anchorage-dependent growth of only those cells that do not overexpress HER2/neu, suggesting that HER2/neu overexpression may counteract the anchorage-dependent growth inhibition mediated by c-myc.

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April 1994
Volume 4 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
MILLER S and MILLER S: HER2 NEU OVEREXPRESSION COUNTERACTS THE GROWTH EFFECTS OF C-MYC IN BREAST-CANCER CELLS. Int J Oncol 4: 965-969, 1994
APA
MILLER, S., & MILLER, S. (1994). HER2 NEU OVEREXPRESSION COUNTERACTS THE GROWTH EFFECTS OF C-MYC IN BREAST-CANCER CELLS. International Journal of Oncology, 4, 965-969. https://doi.org/10.3892/ijo.4.4.965
MLA
MILLER, S., HUNG, M."HER2 NEU OVEREXPRESSION COUNTERACTS THE GROWTH EFFECTS OF C-MYC IN BREAST-CANCER CELLS". International Journal of Oncology 4.4 (1994): 965-969.
Chicago
MILLER, S., HUNG, M."HER2 NEU OVEREXPRESSION COUNTERACTS THE GROWTH EFFECTS OF C-MYC IN BREAST-CANCER CELLS". International Journal of Oncology 4, no. 4 (1994): 965-969. https://doi.org/10.3892/ijo.4.4.965