ANTITUMOR EFFECTS OF POLYVALENT AND MONOVALENT VACCINES COUPLED WITH INTERLEUKIN-2 IN A METASTATIC MELANOMA MODEL

  • Authors:
    • D SHRAYER
    • J KONESS
    • N KOUTTAB
    • H BOGAARS
    • VJ HEARING
    • A MAIZEL
    • HJ WANEBO
  • View Affiliations

  • Published online on: May 1, 1994     https://doi.org/10.3892/ijo.4.5.1121
  • Pages: 1121-1127
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Abstract

We have previously reported that preimmunization of mice with formalinized extracellular antigens (fECA) derived from melanoma cells, in combination with interleukin 2 (IL-2) treatment and surgical resection, decreased subsequent tumor growth and increased survival of mice in a new model for spontaneous metastasis of melanoma. In this study, we have modified the sequence of tumor growth and therapy to more closely mimic the clinical situation. Mice were challenged subcutaneously in the tail with 5 x 10(5) B16 F10 melanoma cells and, by day 21, all of them had developed localized melanoma tumors. The primary tumor-bearing tails of control and experimental animals were then resected distal to the base of the tail, and therapy of the mice was initiated the following day. Groups of mice received different polyvalent and monovalent murine melanoma vaccines (including native or formalin treated extracellular antigens, intact melanoma cells, or purified B700 antigen), with or without concomitant low doses of IL-2. The results demonstrate that the vaccine therapies elicited significant increases in survival of the mice, accompanied by reductions in the size of lymph nodes and in the number of pulmonary metastases. These effects, particularly with the intact melanoma cell vaccine, could be improved even further with concomitant IL-2 treatment.

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May 1994
Volume 4 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
SHRAYER D, KONESS J, KOUTTAB N, BOGAARS H, HEARING V, MAIZEL A and WANEBO H: ANTITUMOR EFFECTS OF POLYVALENT AND MONOVALENT VACCINES COUPLED WITH INTERLEUKIN-2 IN A METASTATIC MELANOMA MODEL. Int J Oncol 4: 1121-1127, 1994
APA
SHRAYER, D., KONESS, J., KOUTTAB, N., BOGAARS, H., HEARING, V., MAIZEL, A., & WANEBO, H. (1994). ANTITUMOR EFFECTS OF POLYVALENT AND MONOVALENT VACCINES COUPLED WITH INTERLEUKIN-2 IN A METASTATIC MELANOMA MODEL. International Journal of Oncology, 4, 1121-1127. https://doi.org/10.3892/ijo.4.5.1121
MLA
SHRAYER, D., KONESS, J., KOUTTAB, N., BOGAARS, H., HEARING, V., MAIZEL, A., WANEBO, H."ANTITUMOR EFFECTS OF POLYVALENT AND MONOVALENT VACCINES COUPLED WITH INTERLEUKIN-2 IN A METASTATIC MELANOMA MODEL". International Journal of Oncology 4.5 (1994): 1121-1127.
Chicago
SHRAYER, D., KONESS, J., KOUTTAB, N., BOGAARS, H., HEARING, V., MAIZEL, A., WANEBO, H."ANTITUMOR EFFECTS OF POLYVALENT AND MONOVALENT VACCINES COUPLED WITH INTERLEUKIN-2 IN A METASTATIC MELANOMA MODEL". International Journal of Oncology 4, no. 5 (1994): 1121-1127. https://doi.org/10.3892/ijo.4.5.1121