Role of endothelin receptor signalling in squamous cell carcinoma

  • Authors:
    • Shunsuke Ishimoto
    • Koichiro Wada
    • Noriaki Tanaka
    • Tadashi Yamanishi
    • Kohji Ishihama
    • Tomonao Aikawa
    • Masaya Okura
    • Atsushi Nakajima
    • Mikihiko Kogo
    • Yoshinori Kamisaki
  • View Affiliations

  • Published online on: November 10, 2011     https://doi.org/10.3892/ijo.2011.1258
  • Pages: 1011-1019
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Abstract

Endothelin plays important roles in various physiological functions including vascular constriction. Recent studies reported that the endothelin receptors ETA and ETB are highly expressed in lung and skin tumor tissues. In contrast, there are few reports on endothelin signalling in the proliferation of head and neck cancer. We found that both ETA and ETB endothelin receptors were overexpressed in tumor cells of tongue cancer samples by immunohistochemistry. ETA and ETB were expressed in cultured lingual and esophageal squamous cell carcinoma (SCCs) cell lines. When both cultured cell lines were treated with an ETA selective antagonist (BQ123) or an ETB selective antagonist (BQ788), inhibition of cell growth was observed. Similar results were observed when SCCs were treated with specific siRNA for the suppression of ETA or ETB. Furthermore, inhibition of the mitogen-activated protein (MAP) kinase pathway by the treatments with ET receptor antagonists and siRNA was also observed. These results indicate that endothelin signalling may, in part, play important roles in cell growth in SCCs through the MAP kinase pathway.
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April 2012
Volume 40 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Ishimoto S, Wada K, Tanaka N, Yamanishi T, Ishihama K, Aikawa T, Okura M, Nakajima A, Kogo M, Kamisaki Y, Kamisaki Y, et al: Role of endothelin receptor signalling in squamous cell carcinoma. Int J Oncol 40: 1011-1019, 2012
APA
Ishimoto, S., Wada, K., Tanaka, N., Yamanishi, T., Ishihama, K., Aikawa, T. ... Kamisaki, Y. (2012). Role of endothelin receptor signalling in squamous cell carcinoma. International Journal of Oncology, 40, 1011-1019. https://doi.org/10.3892/ijo.2011.1258
MLA
Ishimoto, S., Wada, K., Tanaka, N., Yamanishi, T., Ishihama, K., Aikawa, T., Okura, M., Nakajima, A., Kogo, M., Kamisaki, Y."Role of endothelin receptor signalling in squamous cell carcinoma". International Journal of Oncology 40.4 (2012): 1011-1019.
Chicago
Ishimoto, S., Wada, K., Tanaka, N., Yamanishi, T., Ishihama, K., Aikawa, T., Okura, M., Nakajima, A., Kogo, M., Kamisaki, Y."Role of endothelin receptor signalling in squamous cell carcinoma". International Journal of Oncology 40, no. 4 (2012): 1011-1019. https://doi.org/10.3892/ijo.2011.1258